Sentences with phrase «phenotyping using»

To characterize activation of immune cells, measurement of intracellular signaling using phospho - specific antibodies combined with immune phenotyping using surface markers is ideal.

DNA phenotyping uses genes from human remains to give police an idea of what an unknown person looked like.

His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.

Lerner emphasized that this was the first demonstration of screening for the prevention - of - cell - death phenotype using very large antibody libraries — but it won't be the last.

His lab has developed a screen to identify small molecules that revert PSCs to their quiescent phenotype using the accumulation of lipid droplets as a hallmark of the quiescent state.

Stem Cell Differentiation: Electrical Differentiation of Mesenchymal Stem Cells into Schwann - Cell - Like Phenotypes Using Inkjet - Printed Graphene Circuits by Suprem R. Das, Metin Uz, Shaowei Ding, Matthew T. Lentner, John A. Hondred, Allison A. Cargill, Donald S. Sakaguchi, Surya Mallapragada, Jonathan C. Claussen.

Aim 3: We are specifically interested how defects of nuclear proteins cause axonal phenotypes using live cell imaging techniques, inhibitor studies, laser irradiation, - omics approaches.

Not exact matches

Using advances in genomic sequencing, the human microbiome, proteomics, informatics, computing, and cell therapy technologies, HLI is building the world's most comprehensive database of human genotypes and phenotypes as a basis for a variety of commercialization opportunities to help solve aging related disease and human biological decline.

Especially since there is no timeline that can be used to predict the rate of change, especially in the phenotype.

The concept of race (based on phenotype — such as the amount of melanin in the skin — this is what Chad means when he uses the word) has largely been discredited and discarded due to our recent understanding of the human genome.

«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.

The objective of the research project led by Marko Kallio, Principal Scientist at VTT, was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype, but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.

«We are making the scoring software freely available and hope this work will enable transdiagnostic dimensional phenotypes to be used in efforts to achieve precision psychiatry,» said Dr. McCoy.

I combine fundamental research on the genetics of human appearance with applied research such as forensic DNA phenotyping, which is using the prediction of appearance from DNA as a tool in police investigations.

It may be possible to use phenotypes to pick out patients who don't know they've been bitten and have not been formally diagnosed.

In addition to helping farmers check crop health, the new system will be helpful for studying how plants respond to changes in growing conditions and for high - throughput phenotyping, an automated method used in crop research and development to analyze how genetic modifications affect plant characteristics such as leaf size or drought resistance in a large number of plants.

Alternatively, a breeder could, using individuals of differing phenotypes, create a new breed with specific characteristics.

Learn about the latest approaches to assessing cancer - immune interactions («immune profiling») using FFPE tissue sections, multiplexed immunofluorescence, and cell phenotyping software

Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context.

«To describe some of these cell phenotypes we were using lab words such as skinny wiggly cells, chubby wavy cells or zig - zagging sausages,» says Dr Grieneisen.

First author Antonio Di Meco and colleagues used a triple transgenic (3xTg) mouse model that displays an AD - like phenotype, including cognitive decline, and Aβ and tau neuropathology characteristic of the disease in humans.

He is also developing a robust and comprehensive panel of 3 - D cell culture models from patient - derived primary cells that can be used to characterize different disease phenotypes and investigate the chemo - response of cells to novel or known drugs.

The scientific community uses knockout mice to analyze basal phenotypes (the appearance of genetic characteristics) to analyze the function of such a large number of genes.

The term phenotype is sometimes used as a synonym for trait in common use, but strictly speaking, does not indicate the trait, but the state of that trait (e.g., the trait eye color has the phenotypes blue, brown and hazel).

But these individuals can have a range of phenotypes, i.e. look and behave differently, due to random processes in the cells that influence how the genetic instructions are used.

Phevor works by using algorithms that combine the probabilities of gene mutations being involved in a disease with databases of phenotypes, or the physical manifestation of a disease, and information on gene functions.

Frequently, the term cloning is misleadingly used to refer to the identification of the chromosomal location of a gene associated with a particular phenotype of interest.

Cardiovascular phenotyping between the ages of 60 and 64 years with carotid intima media thickness (cIMT; a surrogate marker for cardiovascular events) was used to assess the effect of lifetime exposure to adiposity on cardiovascular risk factors.

Tan and other researchers in the laboratory of Georgia Tech Professor Lin Jiang tested that hypothesis using P. fluorescens, which rapidly evolves into two general phenotypes differentiated by the ecological niches they adopt in static test tube microcosms.

Neither the selective pressure nor the evolutionary response could have been identified with the methods used by the majority of studies that examine how wild populations respond to environmental changes, which predominantly concentrate on changes in the phenotype.

By using antibiotics and microbiota transplantation, the investigators showed that gut microbiota plays a causal role in dietary CAP - induced protective phenotype against high - fat - diet - induced CLGI and obesity.

«Our approach to use a combination treatment of DHCA and Mal - gluc to simultaneously inhibit peripheral inflammation and modulate synaptic plasticity in the brain works synergistically to optimize resilience against chronic stress - induced depression - like phenotypes,» said Dr. Pasinetti.

«Metabolomics is now often used to accompany large genomic cohort studies from biobanks, to correlate genotype and genomic variants with specific phenotypes, to complement nutritional studies monitoring food components or endogenous metabolites, or to support measurements in epidemiology studies,» says Andreas Huhmer, director of proteomics and metabolomics marketing at Thermo Fisher Scientific, headquartered in Waltham, Massachusetts.

That helps them avoid serious problems caused by too much hemoglobin, but Tibetans with this so - called decreased hemoglobin phenotype must somehow use small amounts of oxygen efficiently to get enough of it to their limbs while exercising at high altitude.

Scientists have already used the resource to identify hundreds of thousands of gene - phenotypes associations, many of which are completely new.

All significant phenotypes listed here were assessed using the DSQ and only include ME / CFS individuals

Arguably, the most economical and efficient strategy for development of small molecules with regenerative medicine applications is to use non-mammalian animal models for both target - and phenotype - based drug discovery.

Harmonising ontological descriptions of phenotype in mouse and human and improving links between mouse model data and human data, using diabetes and obesity as examples, will increase the relevance of data that is generated in mouse studies for clinical studies.

Systematic broad - based phenotyping is performed by each IMPC center using standardized procedures found within the International Mouse Phenotyping Resource of Standardised Screens (IMPReSSphenotyping is performed by each IMPC center using standardized procedures found within the International Mouse Phenotyping Resource of Standardised Screens (IMPReSSPhenotyping Resource of Standardised Screens (IMPReSS) resource.

Individual clinical phenotypes were measured using regression models in PLINK [36].

The phenotyping pipeline that will be used within INFRAFRONTIER - I3 builds on the EUMODIC pipeline and uses a cohort of seven female and seven male mutant mice for a comprehensive first - line phenotyping analysis.

Through the use of immunological, molecular and cell biological techniques, my laboratory is defining the phenotype and function of different monocyte subsets that infiltrate the central nervous system following traumatic injury.

Support attendees in use of European and international resources for mouse phenogenomics (cryopreservation, distribution and phenotyping data lines already characterized and available to the scientific community).

More specifically, we use large - scale data acquisition and quantitative modelling of phenotypes and molecular profiles, systematic perturbations (such as drugs or high - throughput genetics) and computational analysis of non-linear, epistatic interaction networks.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

The ability to isolate pure CSC populations using cellular markers has led to advances in our understanding of the heterogeneity and plasticity of the CSC phenotype.

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 X4 Titration of infectivity (TCID50 / ml): 10e6.6 SUBTYPE: F1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides

10:35 - 10:55 Johan Lindberg, Swetox and Jonathan Benskin, Stockholm University, Dept. Applied Environmental Science Molecular phenotyping in zebrafish using metabolomics

Biomarkers predictive of disease phenotype will be validated using existing, publicly available studies by deciphering microbiome characteristics and commonalities associated with healthy and disease states.

That new method for analysis could become a standard way of phenotyping mice, Fallon said, and the ACBM system is now in use in other research at Brown on ALS, and inquiries about the system have started to come from beyond campus, he added.