Furthermore, theoretical calculations on diphosphine capped gold clusters often involve the substitution of simpler hydrogen atoms in the place of computationally demanding substituents such as
phenyl groups with the assumption that the substitution does not alter the stability of the cluster.
The team prepared two gold cluster solutions that differed only in the substitution of either cyclohexane groups or
phenyl groups at the phosphorus centers of diphosphine ligands.
This required both the interactions between
the phenyl groups and the proton pathway.
«As a result of screening about 200 compounds, we found that (3 - furyl) diphenylmethane (chem7), which is a triarylmethane that contains 2
phenyl groups and a furyl (a 5 - membered aromatic ring containing 4 carbons and an oxygen atom in the ring) group, had strong inhibitory activity on plant cell division,» says Ueda.
The chains are bound together by
phenyl groups of the BTC, which form impenetrable walls for the light.
It is a mono - substituted benzene derivative, consisting of a CH ₃ group attached to
a phenyl group.
Not exact matches
Among the halogen substituents at position 4 of the
phenyl ring within D - Phe2, fluorine showed to be optimal, since chlorine and bromine, or even a nitro
group, negatively affected the activity profile of 26, 27, 28 and 29 (IC50 = 0.035, 0.79, 0.57 and 0.94 μM, respectively).
On the other hand, in order to reduce the basicity of the amine, addition of electron withdrawing
groups on the
phenyl ring, such as F (e.g. 132) and CF3 (e.g. 133), led to compounds with high absorption potentials, but, with a concomitant loss of antiviral activity.