Sentences with phrase «phenyl ring»

Subsequently, the order of preferred positions of fluorine on the phenyl ring of D - Phe1 was determined to be as ortho, meta, para (22 > 23 > 16; IC50 = 0.059, 0.088 and 0.22 μM, respectively).

On the other hand, in order to reduce the basicity of the amine, addition of electron withdrawing groups on the phenyl ring, such as F (e.g. 132) and CF3 (e.g. 133), led to compounds with high absorption potentials, but, with a concomitant loss of antiviral activity.

SAR studies indicated that the central aromatic ring is crucial for high CXCR4 affinity, and that a one - carbon separation between the central aromatic phenyl ring and the nitrogen of the acyclic linker is strictly required for potency.

Among the halogen substituents at position 4 of the phenyl ring within D - Phe2, fluorine showed to be optimal, since chlorine and bromine, or even a nitro group, negatively affected the activity profile of 26, 27, 28 and 29 (IC50 = 0.035, 0.79, 0.57 and 0.94 μM, respectively).

Not exact matches

«As a result of screening about 200 compounds, we found that (3 - furyl) diphenylmethane (chem7), which is a triarylmethane that contains 2 phenyl groups and a furyl (a 5 - membered aromatic ring containing 4 carbons and an oxygen atom in the ring) group, had strong inhibitory activity on plant cell division,» says Ueda.