Sentences with phrase «phosphatase which»

The first enzyme is alkaline phosphatase which is necessary for bone mineralization to take place.

Not exact matches

The drug works by inhibiting an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which seems to contribute to cells losing their sensitivity to insulin.

Dopamine and adenosine 3 ′, 5 ′ - monophosphate — regulated phosphoprotein (32 kilodaltons)(DARPP - 32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor.

When these building blocks interact with a cervical cancer biomarker known as glycosylphosphatidylinositol - anchored placental alkaline phosphatase, or GPI - anchored PLAP, which is located on lipid rafts, they self - assemble into nano - scale chains, or «nanofibrils», that glue lipid rafts into large clusters.

These enzymes include basic chitinase, which breaks down chitin — the major component of insects» hard, exterior exoskeletons — and purple acid phosphatase, which enables plants to obtain phosphorus, a critical nutrient, from victims» body parts.

The scientists then reversed this process and the synthetic liquid organelles reformed by adding another type of enzyme, called a phosphatase, which removed the phosphate group from the peptides, reestablishing their positive charge.

Transmission of signals in a cell is controlled by the coordinated activity of two families of enzymes: protein tyrosine kinases, which add a phosphate group to proteins, and protein tyrosine phosphatases, which remove them.

Since alkaline phosphatase, coupled to the secondary antibody for the BrdU primary antibody, may have complicated the interpretation of the wounding experiments, we also treated human corneal - limbal tissues with BrdU histochemical assays in which fluorescein, rather than alkaline phosphatase, was coupled to the secondary antibody.

That, in turn, activates an inducible reporter gene, which expresses a secreted form of alkaline phosphatase.

PTP1B, which I just introduced, is a phosphatase that has been shown to bind and dephosphorylate this IRS - 1, but also can even dephosphorylate the insulin receptor itself.

This phosphatase is a member of a large family of phosphatases, which are involved in dephosphorylating the insulin receptor.

PTPN22 is involved in the formation of a key protein known as lymphoid tyrosine phosphatase (LYP), which helps control the activity of T and B cells in the immune system.

More recently, we elucidated an additional mechanism of tumor suppression mediated by canonical ephrin - induced EphA2 signaling (Figure 1A), which leads to inhibition of the AKT - mTORC1 oncogenic pathway through interplay of EphA2 with a phosphatase that dephosphorylates the AKT serine / threonine kinase.

When five lines were further expanded and characterized, all demonstrated expression of key pluripotency markers expressed by hESCs, which included: alkaline phosphatase, Nanog, SSEA3, SSEA4, TRA160 and TRA181 (Figure 5A).

Foundation funding has had a great impact on Tonks» research, which has been largely focused on the protein tyrosine phosphatase (PTP) family of enzymes.

In contrast, loss of adhesion induced the phosphatases Dusp4 and -5 (Map - kinase phosphatases), which are inhibitors of the MAP - kinase signaling pathway, whereas contact inhibition induced the quiescent cell - specific transcription inhibitor E2F4.

And we have some liver markers including a ALP or alkaline phosphatase, ALT which is alanine aminotransferase or SG PTZ 01.

The phosphatases, in turn, contain a redox - sensitive cysteine moiety in their catalytic site, which is converted by H2O2 into a sulfenic acid moiety, which renders the phosphatase inactive.

The insulin receptor signaling cascade is inhibited by several phosphatases, including protein tyrosine phosphatase 1B (PTB 1B), phosphatase and tensin homolog on chromosome 10 (PTEN) and SH2 - domain - containing inositol phosphatase (SHIP2), all of which are inactivated by ROS.

Other standout lots were the very strong «Self Portait as a Heel - Part Two,» by Jean - Michel Basquiat (1960 - 1988), Lot 16, shown at the top of this article, an acyrilic and oil paintstick on canvas, 1982, that sold for $ 772,500, well above its high estimate of $ 600,000; two sculptures by Agnes Martin (b. 1912), Lots 17 and 18, which sold for $ 217,000 and $ 233,500, respectively, both considerably over their respective high estimates of $ 45,000 and $ 120,000; «Broadway and 64th Street,» a very good, large oil by Richard Estes (b. 1932), that sold above its $ 300,000 high estimate for $ 354,500; Lot 31, a large canvas from his Rorschach series by Andy Warhol (1928 - 1987) that more than doubled its high estimate and sold for $ 684,500; Lot 13, «Alkaline Phosphatase - Polyethelene Glycol,» by Damien Hirst (b. 1965), 1992, sold for $ 140,000 and had a high estimate of $ 80,000; and Lot 37, «a delightful large acrylic on vinyl tarpaulin by Keith Haring (1958 - 1990) that sold for $ 200,500 and had a high estimate of $ 150,000.