Sentences with phrase «phosphatidylinositol -4-phosphate»

Co-author, «Treatment of A431 Cells with Epidermal Growth Factor (EGF) Induces Desensitization of EGF - Stimulated Phosphatidylinositol Turnover,» The Journal of Biological Chemistry, 1989

The mutation occurs in the phosphatidylinositol - binding clathrin assembly protein (PICALM) gene.

After examining over 300 dogs, Dr. Stern identified a mutation in the phosphatidylinositol - binding clathrin assembly protein (PICALM), a protein that is found in the canine heart, that is associated with the development of SAS in Newfoundland dogs and determined that this particular mutation is passed down to their puppies.

mTORC1 is the central component of the insulin - signaling cascade [insulin / insulin - like growth factor (IGF)-- phosphatidylinositol 3 - kinase (PI3K) pathway)(Fig. 1) that regulates protein synthesis and mRNA translation through 2 primary mechanisms: 1) inactivation of the repressor of mRNA translation, eukaryotic translation initiation factor 4E - binding protein 1 (eIF4E - BP1), and 2) the activation of 70 - kDa ribosomal protein S6 kinase.

Insulin - like growth factor - 1 (IGF - 1) inversely regulates atrophy - induced genes via the phosphatidylinositol 3 - kinase / Akt / mammalian target of rapamycin (PI3K / Akt / mTOR) pathway

Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin - proteasome systems by phosphatidylinositol 3 kinase

Phosphatidylinositol 3 - kinase are a family of enzymes involved in cell function.

I think if you benefit from it it suggests you are probably deficient in a number of other phospholipids to, eg phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, and would benefit by eating phospholipid rich foods like liver, brain, marrow, and egg yolks.

Researchers at the Kyung Hee University in Korea discovered how: like insulin, EGCG [structural formula below] activates the enzyme phosphatidylinositol (PI) 3 - kinase.

Fatty acids differentially influence phosphatidylinositol 3 - kinase signal transduction in endothelial cells: impact on adhesion and apoptosis.

METHODS: We treated 3T3 - L1 adipocytes with 2.5 mmol / l R (+) alpha - lipoic acid for 2 to 60 min, followed by assays of: 2 - deoxyglucose uptake; glucose transporter 1 and 4 (GLUT1 and GLUT4) subcellular localization; tyrosine phosphorylation of the insulin receptor or of the insulin receptor substrate - 1 in cell lysates; association of phosphatidylinositol 3 - kinase activity with immunoprecipitates of proteins containing phosphotyrosine or of insulin receptor substrate - 1 using a in vitro kinase assay; association of the p85 subunit of phosphatidylinositol 3 - kinase with phosphotyrosine proteins or with insulin receptor substrate - 1; and in vitro activity of immunoprecipitated Akt1.

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate - 1 (IRS - 1)- associated phosphatidylinositol 3 - kinase activity in muscle.

The balance between kinase and phosphatase activities determines the rate of phosphorylation of the insulin receptor kinase domain and several downstream targets including the phosphatidylinositol phosphates, the serine / threonine kinase Akt1 and the mTOR.

The phosphatidylinositol pathway, on the other hand, is triggered by the Gq - coupled receptors.

Antigen - specific enhancement of natural human IgG antibodies to phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol -4-phosphate, cholesterol, and lipid A by a liposomal vaccine Containing lipid A.Vaccine.

Phosphatidylinositol -3-kinase (PI3K) inhibitors (LY294002 (10 μM) and wortmannin (10 μM)-RRB- and an AKT inhibitor (deguelin (0.1 or 0.2 μM)-RRB- were added to the 293, 293T, HepG2, and Hepa - 1c1c7 cells that had been treated with ActD.

In what concerns intra-membrane constituents, the focus of interest has been on phosphatidylinositol lipids and their capacity to orchestrate endocytic events on the cytosolic leaflet of the membrane.

Inositol is a sugar that can serve as a precursor for a membrane phospholipid (phosphatidylinositol), a second messenger in signal transduction, an osmolyte, or an energy source.

This, in turn, is actually a lipid kinase and it phosphorylates lipids on the plasma membrane, making a new or synthesizing a new phosphate or a lipid phosphatidylinositol lipid called PIP - 3.

Association of phosphatidylinositol 3 - kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.

Interestingly, PDGF - BB overexpression by modified hDPSCs enhanced the recruitment of hDPSCs both in vitro and in vivo via the activation of the phosphatidylinositol 3 kinase (PI3K) / Akt signaling pathway and, in combination with secreted vascular endothelial growth factor (VEGF), enhanced in vitro angiogenesis.

[41] Approximately 50 % of cutaneous melanomas have an activating BRAF mutation, with an additional 10 % to 20 % having an activating mutation in NRAS; NRAS is an upstream partner of BRAF that also activates the phosphatidylinositol 3 - kinase (PI3K) / Akt / mammalian target of rapamycin (mTOR) pathway.

Metlakunta AS, Sahu M, Sahu A. Hypothalamic phosphatidylinositol 3 - kinase pathway of leptin signaling is impaired during the development of diet - induced obesity in FVB / N mice.

AKT is a downstream effector of phosphatidylinositol 3 - kinase (PI3K) and a critical mediator of mammalian target of rapamycin (mTOR) activity (6).

The membrane associated adaptor ankyrin - B (AnkB) promotes fast axonal transport and elongation by coupling dynactin to multiple organelles through binding to phosphatidylinositol 3 - phosphate lipids in these cargos.

Phosphatidylinositol 3, 5 - bisphosphate increases intracellular free Ca2 + in arterial smooth muscle cells and elicits vasocontraction.

Stimulation of the TCR results in cleavage of phosphatidylinositol 4,5 - bisphosphate to form inositol 1,4,5 - trisphosphate, which induces intracellular calcium flux, and DAG, which binds to RasGRP1 and PKC - θ to contribute to activation of these proteins (28).

Proteomic identification of phosphatidylinositol (3, 4, 5) triphosphate - binding proteins in Dictyostelium discoideum.

Phosphatidylinositol -4-Kinase Type II Alpha Contains an AP - 3 — sorting Motif and a Kinase Domain That Are Both Required for Endosome Traffic.

Hepatitis C virus stimulates the phosphatidylinositol 4 - kinase III alpha - dependent phosphatidylinositol 4 - phosphate production that is essential for its replication.

Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3 - kinase / Akt / mTOR pathway and inhibition of autophagy.

Cbl - b targets the p85α subunit of PI (3) K for degradation, resulting in termination of substrate activation downstream of phosphatidylinositol 3,4,5 - triphosphate (21).

GOLPH3 bridges phosphatidylinositol -4-phosphate and actomyosin to stretch and shape the Golgi to promote budding.

Burke specifically studies the phosphoinositide 3 - kinase and phosphatidylinositol 4 - kinase families.

Cbl - b, a RING - type E3 ubiquitin ligase, targets phosphatidylinositol 3 - kinase for ubiquitination in T cells.

Platelet - activating factor - mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3 - kinase in human neutrophils.

Phosphatidylinositol 4 - kinase III - β is required for Golgi maintenance and cytokinesis in Trypanosoma brucei.

Research in the Emerling Lab is focused on phosphoinositide signaling, in particular the role of the phosphatidylinositol -5-phosphate 4 - kinases (PI5P4Ks) in cancer metabolism.

Estrogen receptor protein interaction with phosphatidylinositol 3 - kinase leads to activation of phosphorylated Akt and extracellular signal - regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action.

Molecular genesis of cutaneous melanoma pathways; rous avian sarcoma homologue (Ras); v - raf murine sarcoma viral oncogene homologue B1 (BRAF); mitogen - activated protein kinase (MEK); extracellular signal - regulated kinase (ERK); microphthalmia transcription factor (Mitf); phosphatidylinositol - 3 kinase (PI3K); murine v - akt oncogene homologue (Akt).

Structure / Function Analysis of the Interaction of Phosphatidylinositol 4, 5 - Bisphosphate with Actin - capping Protein.

The protein encoded by the PIK3C2G gene belongs to the phosphatidylinositol -4,5-bisphosphonate 3 - kinase (PI3K) family, which plays a critical role in cancer.28 Experimental evidence suggests that activation of PI3K signaling enhances production of COX - 2 and PGE2, which results in inhibition of apoptosis in colon cancer cell lines that can be restored with NSAID - mediated blockade of PI3K.29

Western blot analyses with phospho - specific antibodies suggested that stretching induces phosphorylation of ERK of the MAP kinase pathway, but did not induce phosphorylation of phosphatidylinositol 3 - kinase.

Moreover, our previous study found that regular use of aspirin after diagnosis was associated with longer survival among the 15 % to 30 % of patients with colorectal cancer and with a mutation in phosphatidylinositol -4,5-bisphosphate 3 - kinase, catalytic subunit alpha (PIK3CA [NCBI Entrez Gene 5290]-RRB-, one of the PI3K family genes.30 Markedly improved survival associated with aspirin according to PIK3CA status was also found in an analysis within a separate clinical trial cohort.31 Further investigations for the joint effect of these genes would be helpful to better understand the underlying molecular mechanisms of aspirin, NSAIDs, and colorectal cancer.

PREX2: phosphatidylinositol -3,4,5-triphosphate-dependent RAC exchange factor 2.

We regenerated cells stably expressing ectopic wild - type and mutant phosphatidylinositol -3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2) using the same immortalized human NRASG12D melanocytes as the original study.

PTEN can also reduce the levels of another similar molecule known as phosphatidylinositol -3,4-bisphosphate (PI (3,4) P2).

Here's the scientific description: «In this process, the capsaicin receptor (TRPV1) is sensitized by phosphatidylinositol -4,5-bisphosphate (PIP2) hydrolysis following phospholipase C activation.»