Sentences with word «phosphoinositide»

Indeed, one of Burke's major contributions to science involves the screening of phosphoinositide kinase inhibitors that may yield potential treatments.

«For the first time, it appears that a monoclonal antibody that binds only to highly purified intracellular phosphoinositide lipids, and not to any of 17 other types of lipids or to HIV protein, results in the secretion of HIV - inhibitory beta - chemokines.»

Virus binding to cognate receptors also can regulate phosphoinositide kinases.

Among these were several putative transcripts with homology to serine / threonine protein kinase, serine / threonine - specific protein phosphatase and phosphoinositide phospholipase C.

Research in the Emerling Lab is focused on phosphoinositide signaling, in particular the role of the phosphatidylinositol -5-phosphate 4 - kinases (PI5P4Ks) in cancer metabolism.

Dr Ghigo's research focuses on the enzyme phosphoinositide 3 - kinase gamma (PI3K?)

Phosphoinositides in Ca2 + signaling and excitation - contraction coupling in skeletal muscle: an old player and newcomers.

3 - Define how phosphoinositides (PtdInsPs) are involved in the control of intracellular Ca2 + + and determine whether this plays a role in muscle dysfunctions due to deficient PtdInsPs metabolism.

Although phosphoinositides are also constituents of HIV, in the absence of HIV they are located only inside cells,» said lead investigator Carl Alving, M.D. with the Division of Retrovirology at the Walter Reed Army Institute of Research.

This leads to activation of a kinase; a very important kinase in metabolism called PI3 - Kinase, standing for phosphoinositide or 3 - Kinase.

Since PIP and PIP2 and other phosphoinositides do not exist on the outside surface of cells, this study suggests that one or more of the cells in the PBMC population might have internalized the antibody to bind to intracellular lipids and caused the release of molecules that inhibit HIV infection.

The WR321 antibody is unique in that it specifically binds only to phosphatidylinositol phosphate (PIP) and phosphatidylinositol bisphosphate (PIP2), which are two of the seven phosphoinositide molecules that are precursors of important intracellular signaling molecules.

Regulation of D - 3 phosphoinositides during T cell activation via the T cell antigen receptor / CD3 complex and CD2 antigens.

Different inhibition of Gβγ - stimulated class IB phosphoinositide 3 - kinase (PI3K) variants by a monoclonal antibody.

PLC - beta is a 150 kDa enzyme that catalyzes the hydrolysis of phosphoinositide PtdIns (4,5) P2 located in the plasma membrane into diacylglcyerol (DAG) and Ins (1,4,5) P3.

In addition to Sauer, Eugene Park of Washington University School of Medicine was a co-first author of the study, «Inositol Tetrakisphosphate Limits NK Cell Effector Functions by Controlling Phosphoinositide 3 - Kinase Signaling.»

Surprisingly, mobility of phosphoinositides was nearly completely frozen in these BAR domain induced lipid platforms.

The symposium will cover this fascinating and often neglected field from lipid biology and phosphoinositide signaling to membrane transport and intramembrane enzymes.

Phosphoinositide kinases are regulated by upstream cell - signaling events.

This property required exon 10, a phosphoinositide - binding module.

It is well known that seizures produce learning, memory and behavioral deficits, and that they trigger abnormally high activity of two signaling pathways in the brain: the phosphoinositide 3 - kinase (PI3K) and mechanistic target of rapamycin (mTOR) cascades.

The researchers, from Kings College London, also found evidence of a close relationship between PAK4 and a well - researched cancer pathway called the phosphoinositide 3 - kinase pathway (PI3K).

In a new study published in Cell Reports, Hongxia Zhao working in the Lappalainen laboratory discovered that all BAR domain proteins induce strong clustering of phosphoinositides, which are important lipids involved in regulating protein functions and cellular signalling.

MicroRNA -7-5p regulates the proliferation and migration of intestinal epithelial cells by targeting trefoil factor 3 via inhibiting the phosphoinositide 3 - kinase / Akt signalling pathway.

Burke specifically studies the phosphoinositide 3 - kinase and phosphatidylinositol 4 - kinase families.

Burke's work focuses primarily on the kinases and phosphatases that catalyze the phosphorylation and dephosphorylation of lipid phosphoinositides.

That work is carried out through a molecular pathway known as PI3K — phosphoinositide 3 kinase — an enzyme Cantley discovered during the 1980s that relays signals and activates other enzymes or genes.

Decreased amounts of the lipid family of phosphoinositides (PIPs) in the plasma membrane have been shown to cause cytokinesis defects.

AFM - Téléthon (2015 - 2016): Phosphoinositides and Ca2 + signaling in normal and diseased skeletal muscle (coordinator).

Using standard enzyme - linked immunosorbent assays (ELISA) and peripheral blood mononuclear cell (PBMC) assays, researchers discovered that unlike previously described human antibodies to lipids, WR321 did not react with any of 17 other lipids it was tested against, including cholesterol, glycolipids, and other phospholipids such as cardiolipin and phosphatidylserine, but it bound specifically only to two phosphoinositides.

Investigators compared WR321, a non-human monoclonal IgG antibody that binds to phosphoinositide lipids, developed by Dr. Gary Matyas at MHRP, with a human monoclonal IgG antibody that in recent studies was found to have lipid - binding characteristics, including binding to phosphoinositides, but also bound to numerous other lipids.

Two such signposts are the Rab GTPases and different species of phosphoinositide.

Inhibitory role of alpha6beta 4 - associated erbB - 2 and phosphoinositide 3 - kinase in keratinocyte haptotactic migration dependent on alpha3beta1 integrin.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

Additional research will be needed to determine the exact binding site of the antibody and to identify the specific mechanism by which binding of the antibody to the phosphoinositide lipid may have caused secretion of the beta - chemokines.

John E. Burke's work focuses primarily on the kinases and phosphatases that catalyze the phosphorylation and dephosphorylation of lipid phosphoinositides.

Of particular significance was the development of chemical methods to convert highly polar signalling molecules like cyclic nucleotides, inositol phosphates, and phosphoinositides to membrane - permeant, bioactivatable derivatives («prodrugs»)(Schultz 2003; Laketa et al. 2009, Laketa et al. 2014).

Inhibition of HIV - 1 infection of peripheral blood mononuclear cells by a monoclonal antibody that binds to phosphoinositides and induces secretion of β - chemokines.