Sentences with phrase «phosphoinositide ptdins»

One of the serine / threonine protein kinases (JGI ID: 432478) was upregulated nearly sevenfold in the future ocean condition treatment, whereas a phosphoinositide phospholipase C (JGI ID: 95985) increased expression sixfold (see electronic supplementary material, table S5).

In addition, leucine has been shown to modulate insulin / phosphoinositide 3 - kinase signaling in animal models (10), and cysteine has been shown to increase glucose uptake and concentrations of glucose transporter 3 and glucose transporter 4 in vitro; in rat models, dietary cysteine has been shown to reduce insulin resistance and glucose intolerance (11, 12).

Polymorphic variants of insulin - like growth factor I (IGF - I) receptor and phosphoinositide 3 - kinase genes affect IGF - I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control.

TORC1, Target of rapamycin complex 1; PI3K, Phosphoinositide 3 - kinase; SNARE, Soluble N - ethylmaleimide - sensitive factor Attachment protein REceptors.

Phosphoinositide - dependent and - independent natural cell killing of pre-B acute lymphoblastic leukemia cells by IL - 2 activated NK cells and NK - 92ci Clin Exp Immunol.

PLC - beta is a 150 kDa enzyme that catalyzes the hydrolysis of phosphoinositide PtdIns (4,5) P2 located in the plasma membrane into diacylglcyerol (DAG) and Ins (1,4,5) P3.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Different inhibition of Gβγ - stimulated class IB phosphoinositide 3 - kinase (PI3K) variants by a monoclonal antibody.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

Inhibitory role of alpha6beta 4 - associated erbB - 2 and phosphoinositide 3 - kinase in keratinocyte haptotactic migration dependent on alpha3beta1 integrin.

Vorinostat interferes with the signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3 kinase inhibitors in cutaneous T - cell lymphoma

This leads to activation of a kinase; a very important kinase in metabolism called PI3 - Kinase, standing for phosphoinositide or 3 - Kinase.

«For the first time, it appears that a monoclonal antibody that binds only to highly purified intracellular phosphoinositide lipids, and not to any of 17 other types of lipids or to HIV protein, results in the secretion of HIV - inhibitory beta - chemokines.»

Two such signposts are the Rab GTPases and different species of phosphoinositide.

Investigators compared WR321, a non-human monoclonal IgG antibody that binds to phosphoinositide lipids, developed by Dr. Gary Matyas at MHRP, with a human monoclonal IgG antibody that in recent studies was found to have lipid - binding characteristics, including binding to phosphoinositides, but also bound to numerous other lipids.

The symposium will cover this fascinating and often neglected field from lipid biology and phosphoinositide signaling to membrane transport and intramembrane enzymes.

Phosphoinositide Binding Differentially Regulates NHE1 Na + / H + Exchanger - dependent Proximal Tubule Cell Survival.

Phosphoinositide Binding by the Toll Adaptor dMyD88 Controls Antibacterial Responses in < i > Drosophila .

Phosphorylation of Src by phosphoinositide 3 - kinase regulates beta - adrenergic receptor - mediated EGFR transactivation.

Burke specifically studies the phosphoinositide 3 - kinase and phosphatidylinositol 4 - kinase families.

Phosphoinositide Binding by the Toll Adaptor dMyD88 Controls Antibacterial Responses in < i > Drosophila % U http://www.sciencedirect.com/science/article/pii/S1074761312000970.

Research in the Emerling Lab is focused on phosphoinositide signaling, in particular the role of the phosphatidylinositol -5-phosphate 4 - kinases (PI5P4Ks) in cancer metabolism.

Virus binding to cognate receptors also can regulate phosphoinositide kinases.

MicroRNA -7-5p regulates the proliferation and migration of intestinal epithelial cells by targeting trefoil factor 3 via inhibiting the phosphoinositide 3 - kinase / Akt signalling pathway.

The researchers, from Kings College London, also found evidence of a close relationship between PAK4 and a well - researched cancer pathway called the phosphoinositide 3 - kinase pathway (PI3K).

This property required exon 10, a phosphoinositide - binding module.

Surprisingly, mobility of phosphoinositides was nearly completely frozen in these BAR domain induced lipid platforms.

Phosphoinositides in Ca2 + signaling and excitation - contraction coupling in skeletal muscle: an old player and newcomers.

Decreased amounts of the lipid family of phosphoinositides (PIPs) in the plasma membrane have been shown to cause cytokinesis defects.

Using standard enzyme - linked immunosorbent assays (ELISA) and peripheral blood mononuclear cell (PBMC) assays, researchers discovered that unlike previously described human antibodies to lipids, WR321 did not react with any of 17 other lipids it was tested against, including cholesterol, glycolipids, and other phospholipids such as cardiolipin and phosphatidylserine, but it bound specifically only to two phosphoinositides.

Although phosphoinositides are also constituents of HIV, in the absence of HIV they are located only inside cells,» said lead investigator Carl Alving, M.D. with the Division of Retrovirology at the Walter Reed Army Institute of Research.

Regulation of D - 3 phosphoinositides during T cell activation via the T cell antigen receptor / CD3 complex and CD2 antigens.

John E. Burke's work focuses primarily on the kinases and phosphatases that catalyze the phosphorylation and dephosphorylation of lipid phosphoinositides.

Inhibition of HIV - 1 infection of peripheral blood mononuclear cells by a monoclonal antibody that binds to phosphoinositides and induces secretion of β - chemokines.