Sentences with phrase «phosphoinositide lipids»

«For the first time, it appears that a monoclonal antibody that binds only to highly purified intracellular phosphoinositide lipids, and not to any of 17 other types of lipids or to HIV protein, results in the secretion of HIV - inhibitory beta - chemokines.»

Investigators compared WR321, a non-human monoclonal IgG antibody that binds to phosphoinositide lipids, developed by Dr. Gary Matyas at MHRP, with a human monoclonal IgG antibody that in recent studies was found to have lipid - binding characteristics, including binding to phosphoinositides, but also bound to numerous other lipids.

Not exact matches

Surprisingly, mobility of phosphoinositides was nearly completely frozen in these BAR domain induced lipid platforms.

Decreased amounts of the lipid family of phosphoinositides (PIPs) in the plasma membrane have been shown to cause cytokinesis defects.

The symposium will cover this fascinating and often neglected field from lipid biology and phosphoinositide signaling to membrane transport and intramembrane enzymes.

Using standard enzyme - linked immunosorbent assays (ELISA) and peripheral blood mononuclear cell (PBMC) assays, researchers discovered that unlike previously described human antibodies to lipids, WR321 did not react with any of 17 other lipids it was tested against, including cholesterol, glycolipids, and other phospholipids such as cardiolipin and phosphatidylserine, but it bound specifically only to two phosphoinositides.

John E. Burke's work focuses primarily on the kinases and phosphatases that catalyze the phosphorylation and dephosphorylation of lipid phosphoinositides.