Sentences with word «phospholipase»

His lab has also reported that a different signaling factor called phospholipase C - beta3 (PLC - β3) antagonizes mast cell activation by blocking STAT5.

The scientists confirmed that the drug was inhibiting activation of phospholipase Cγ1 in the mice.

Then, when they infused it into the blood of the mice, pY816 reduced by half the amount of activated phospholipase Cγ1 in the brain.

The free Ca2 + activates an enzyme called phospholipase A2 that starts chewing the fats in the wall of the liposomes and triggers the fast release of the drug.

Wang, T.C., GOLDENRING, J.R., Dangler, C., Millar, A., Jeon, W.K., Ito, S., Koh, T.J. and Fox, J.G. C57BL / 6 mice deficient in secretory phospholipase A2 show increased apoptosis and altered cellular differentiation during Helicobacter felis infection.

Dr. Chung also found, working in collaboration with co-senior author, Robert S. Kass, PhD, the Alumni and David Hosack Professor of Pharmacology, chair of the department, and vice dean for research at CUMC, that the effects of the KCNK3 mutations could be reversed with an experimental phospholipase inhibitor called ONO - RS - 082.

Research Paper Lipoprotein - Associated Phospholipase A2 Activity Level may be complementary to Cardiactroponin I as a Biomarker for Acute Myocardial Infarction in Chinese Patients with Chest Pain Ting Sun, Qian Zhao, Zhaofang Yin, Zuojun Xu, Yang Zhuo, Li Fan, Zhihua Han, Lei Liu, Changqian Wang J. Biomed 2018; 3: 19 - 25.

They found that the strain had acquired the gene for phospholipase A2, called SlaA, in the mid-1980s, which suggested that SlaA was responsible for the jump in virulence.

Tnf - a stimulates the production of Arachidonic Acid via Phospholipase A2 from our cellular lipid stores.

Galphaq activates phospholipase C - beta.

That family includes members that can either act as phospholipases, cleaving phospholipid molecules, or as nucleases, cutting nucleic acid chains.

Among these were several putative transcripts with homology to serine / threonine protein kinase, serine / threonine - specific protein phosphatase and phosphoinositide phospholipase C.

Gatti, C., Cantelmi, M. G., Brunetti, M., Gaiti, A., Calderini, G., and Teolato, S. Effect of chronic treatment with phosphatidyl serine on phospholipase A1 and A2 activities in different brain areas of 4 month and 24 month old rats.

Here's the scientific description: «In this process, the capsaicin receptor (TRPV1) is sensitized by phosphatidylinositol -4,5-bisphosphate (PIP2) hydrolysis following phospholipase C activation.»

The researchers identified liver - specific genes linked to NAFLD pathogenesis, such as pyruvate kinase liver and red blood cell, (PKLR), or to HCC pathogenesis, such as PKLR, patatin - like phospholipase domain containing 3 (PNPLA3) and proprotein convertase subtilisin / kexin type 9 (PCSK9), all of which are potential targets for drug development.

C. krusei, they found, has few copies of gene families associated with pathogenesis in C. albicans, including oligopeptide transporters, aspartyl proteases, and phospholipase B genes.

McNamara's team then developed a small - protein drug, called pY816, to prevent TrkB coupling with phospholipase Cγ1.

The scientists found that transgenic mice in which phospholipase Cγ1 was unlinked from the TrkB receptor were less susceptible to seizures than normal mice.

Structural capsid proteins with three variants: VP1, VP2, and VP3; VP1 possesses phospholipase A2 activity, which is likely necessary to release the AAV particles from late endosomes.

His research has focused on snake venoms, particularly on myotoxic phospholipases A2, and on antivenoms.

Request other tests like LDL - C that measures lipoprotein subtype as well as inflammatory measures like C - reactive protein (CRP), Phospholipase A-1 (PLA - 2), and homocysteine levels.

They suggest that keeping choline levels low outside endosomes promotes the activity of an enzyme, phospholipase D, that cleaves multiple lipids and, in so doing, has a direct effect on vesicle lipid composition and thus destination.

«Inhibition of platelet phospholipase A2 activity by catuaba extract suggests anti-inflammatory properties.»

According to Broady, NSI acts against many venoms because all snakes mix their toxic cocktails from phospholipase A2, an enzyme found in cells.

Some of these benefits appear to take place through the blocking of selectins and from inhibition of an enzyme called phospholipase A2.

Furthermore, anti-CD3 mAb induced phosphorylation of ERK, phospholipase C γ (PLC - γ), and SLP76, all were unaltered in Gasp - deficient DP thymocytes (Fig. 5F).

Thwin M. M., Douni E., Aidinis V., Kollias G., Kodama K., Sato K., Satish R. L., Mahendran R., Gopalakrishnakone P., 2004, «Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time - course ultrastructural study», Arthritis Res.

Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16.

The GTP - alpha subunit complex activates appropriate effectors, such as adenylyl cyclase, retinal phosphodiesterase, phospholipase C, and ion channels.