Sentences with word «phosphonate»

They kept one phosphonate group to act as the base but swapped out the other for a less - tightly - bound carboxylate.

This research demonstrates a new synthetic transformation of dialkylphosphonates to mixed phosphonates under mild reaction conditions.

Moreover, the binding with the MMP active site is discussed in the research paper, «Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors», published in Current Drug Targets.

Anionic groups, such as carboxylate and phosphonate stand out.

This synthetic method avoids the use of toxic metals, hazardous chloride reagents, and moisture sensitive chloride intermediates for the synthesis of biologically important mixed phosphonate compounds.

The mixed phosphonates are prevalent in pharmaceuticals and bioactive small molecules such as antibacterial, ligand prodrug, and enzyme inhibitors.

«We created a MOF that absorbs the phosphonates found in pesticides and nerve gases.

«Phosphonate emerging zinc binding group in matrix metalloproteinase inhibitors: This research contains a comprehensive review of known phosphonate - based MMP inhibitors..»

Phosphonate - based inhibitors are classified on peptide phosphonate; sulphonamide and sulfonyl phosphonate, the most potent; carbamoyl phosphonate, and bisphosphonate that have been identified more recently with an interesting activity on bone resorption.

In this review the phosphonate and bis - phosphonate groups as the ZBG are considered in the development of selective and potent MMPIs.

In the first design, the phosphonate groups were so strongly bound to the metal that they were preventing the water molecule from binding to the catalyst early enough to keep the process running smoothly.

Jun Yong Kang and Hai Huang (both Chemistry and Biochemistry), as well as computational study collaborators at the University of Colorado, Denver, published a research article, «Direct Aryloxylation / Alkyloxylation of Dialkyl Phosphonates for the Synthesis of Mixed Phosphonates,» in Angewandte Chemie.

In fact, bis - phosphonates can actually weaken your bone.

Bis - phosphonates, such as Boniva and Fosmax aren't the magic pill that Big Pharma would like you to believe.