Sentences with phrase «phosphonate group»

They kept one phosphonate group to act as the base but swapped out the other for a less - tightly - bound carboxylate.

In this review the phosphonate and bis - phosphonate groups as the ZBG are considered in the development of selective and potent MMPIs.

In the first design, the phosphonate groups were so strongly bound to the metal that they were preventing the water molecule from binding to the catalyst early enough to keep the process running smoothly.

Not exact matches

Moreover, the binding with the MMP active site is discussed in the research paper, «Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors», published in Current Drug Targets.

«Phosphonate emerging zinc binding group in matrix metalloproteinase inhibitors: This research contains a comprehensive review of known phosphonate - based MMP inhibitoPhosphonate emerging zinc binding group in matrix metalloproteinase inhibitors: This research contains a comprehensive review of known phosphonate - based MMP inhibitophosphonate - based MMP inhibitors..»

Anionic groups, such as carboxylate and phosphonate stand out.