The presence of a great variety of neuron -
specific phosphoproteins in nervous tissue supports the view that protein phosphorylation plays many roles in neuronal function.
Elucidating the essential role of the A14
phosphoprotein in vaccinia virus morphogenesis: construction and characterization of a Tetracycline - inducible recombinant.
After sequencing the elephant shark's genome, the researchers found that the elephant shark genetic code does hold most types of genes needed for bone formation — except for the genes for
secreted phosphoproteins, which could explain why their cartilage doesn't turn to bone.
Relative quantification of original input RNA amounts were calculated by comparison to standard curves using purified PCR product as a template for the mRNAs of interest and were normalized to the amount of acidic ribosomal
phosphoprotein P0 mRNA [24,46].
Inhibition of Interferon Signaling by Rabies Virus
Phosphoprotein P: Activation - Dependent Binding of STAT1 and STAT2
Corticosterone increased the amount of the neuron - specific
phosphoprotein protein 1 in the hippocampus, a brain region rich in corticosterone receptors, but not in several brain regions that contain relatively few corticosterone receptors.
When a protein called stress -
inducible phosphoprotein 1 (STI1) interacts with the prion protein preventing the interaction of amyloid - β peptides, it protects neurons.
Some
neuronal phosphoproteins have been detected throughout the entire nervous system, whereas the distribution of others is limited to one or a few neuronal cell types.
Here, we provide evidence that mTOR
signaling phosphoproteins, including mTOR, eukaryotic initiation factor 4E — binding protein - 1, p70S6K, and ribosomal protein S6, are highly phosphorylated in ALK + ALCL cell lines and tumors.
The syndrome is associated with mutations in the TCOF1 gene which encodes a putative
nucleolar phosphoprotein known as treacle.
DARPP - 32, a dopamine - and adenosine 3 ′, 5 ′ - monophosphate (cAMP)--
regulated phosphoprotein (32 kilodaltons in size), is an obligate intermediate in progesterone (P)-- facilitated sexual receptivity in female rats and mice.
Synapsin I and synapsin II are neuron -
specific phosphoproteins that have a role in the regulation of neurotransmitter release and in the formation of nerve terminals.
CML cells have two novel products: an 8.5 - kilobase RNA transcript containing both abl and bcr and a 210 -
kilodalton phosphoprotein (P210) recognized by v - abl - specific antisera.
Identification of the Rabies Virus Alpha / Beta Interferon Antagonist:
Phosphoprotein P Interferes with Phosphorylation of Interferon Regulatory Factor 3
According to Robert Henkin of The Taste and Smell Clinic in Washington, D.C., casein is
a phosphoprotein that acts as a detergent and strips the capsaicin from the nerve receptor binding sites in the mouth which are contained in the taste papilli.
An international team of scientists led by Newcastle University, UK, and funded by the US Office of Naval Research, have shown for the first time that barnacle larvae release an oily droplet to clear the water from surfaces before sticking down using
a phosphoprotein adhesive.
Corticosterone increases the amount of protein 1, a neuron - specific
phosphoprotein, in rat hippocampus
Dopamine and adenosine 3 ′, 5 ′ - monophosphate — regulated
phosphoprotein (32 kilodaltons)(DARPP - 32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor.
The physiological significance of several of
these phosphoproteins has already been established.
These various neuron - specific
phosphoproteins are proving of value in the study of the physiology, anatomy, developmental biology, and pathophysiology of the nervous system.
While working on this project I established several functional assays (lipolysis, analysis of cytokines, adipokines, and
phosphoproteins using Luminex technology and others).
Two - dimensional polyacrylamide gel electrophoresis combined with chromatographic
phosphoprotein pre-enrichment and electrospray ionization mass spectrometry - based protein identification was used to reveal changes of phosphoproteins in cells exposed to cyclic stretching.