Sentences with word «phosphoproteomics»

Applying these methods to prostate cancer cell lines, the researchers found that accurate predictions of drug sensitivity could be achieved using either genomics data or phosphoproteomics data alone.

This visual abstract depicts how Wei et al. utilize single - cell phosphoproteomic analysis of patient derived glioblastoma models to identify shifts in signaling coordination following short - term treatment with kinase inhibitors, which facilitates the design of combination therapy approaches with reduced resistance and improved efficacy.

Proteomics and phosphoproteomics analyses in melanoma cells identified CDK2 as a driver of resistance to both BRAF and Hsp90 inhibitors.

Zhang X, Maity T, Kashyap M K, Bansal M, Venugopalan A, Singh S, Awasthi S, Marimuthu A, Jacob H K C, Belkina N, Pitts S, Cultraro C M, Gao S, Kirkali G, Biswas R, Chaerkady R, Califano A, Pandey A, Guha U. Quantitative Tyrosine Phosphoproteomics of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor - treated Lung Adenocarcinoma Cells Reveals Potential Novel Biomarkers of Therapeutic Response.

In the new paper, Kajimura's team collaborated with the laboratory of Yasushi Ishihama, PhD, of the University of Kyoto, Japan, to search for differences in how white and brown fat cells respond to the cold using a technique called phosphoproteomics.

Finally, we will carry out a small phosphoproteomics study to identify host proteins whose phosphorylation state changes during T. gondii invasion.

Methods: The PNNL team applied global proteome profiling in combination with UCSD - developed phosphoproteomics approaches to understand signal organization in migrating cells.

Some typical technology platforms are: - Gene expression measurement through DNA microarrays and SAGE - Protein levels through two - dimensional gel electrophoresis and mass spectrometry, including phosphoproteomics and other methods to detect chemically modified proteins.

The transcriptomics and phosphoproteomics data generated by this project will allow the identification of novel host and parasite genes and pathways that play a key role during infection.

The technology the team used is called single - cell phosphoproteomics.

Phosphoproteomic Analysis Reveals the Importance of Kinase Regulation During Orbivirus Infection.

In the paper, the researchers also described that single - cell phosphoproteomics could be used to study how melanoma cells develop resistance to a class of drugs called BRAF inhibitors.

Evan Paull, a graduate student in Stuart's lab at UC Santa Cruz (now at Columbia University), led the computational analyses, which involved integrating the phosphoproteomic data with genomic and gene expression datasets to provide a unified view of the activated signaling pathways in late stage prostate cancer.

Justin Drake, a postdoctoral researcher in Witte's lab at UCLA (now an assistant professor at Rutgers Cancer Institute of New Jersey), led the phosphoproteomics work, producing a new encyclopedia of protein phosphorylation in prostate cancer cells and tissues.

«Having the phosphoproteomics data in addition to the traditional genomics and transcriptomics enabled us to get a more comprehensive view of aberrant signaling in this disease,» Paull said.

Her interests centre on developing methods for quantitative proteomics, phosphoproteomics and methods for tracking changes in sub-cellular localization of the proteome in response to cell signalling events.

He has also been leading statistical data analysis for the Broad Institute's Proteome Characterization Center and Proteogenomic Data Analysis Center established under the National Cancer Institute Clinical Proteomics Tumor Analysis Consortium (CPTAC), focusing on proteogenomic analysis of proteomic, phosphoproteomic, and genomic data derived from cancer samples.

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations.