Mutational analysis of Arabidopsis chloroplast
polynucleotide phosphorylase reveals roles for both RNase PH core domains in polyadenylation, RNA 3 «- end maturation and intron degradation
In addition to needlessly spending more money, doses above 6 mg per 1 kg, have been related to inhibition of
glycogen phosphorylase, an essential enzyme in the metabolism of glycogen.
T - lymphocyte dysfunction in the elderly associated with zinc deficiency and subnormal
nucleoside phosphorylase activity: effect of zinc supplementation
In patients with the blood cancer multiple myeloma, an enzyme called
thymidine phosphorylase sets off a chain reaction that leads to bone destruction, researchers report August 24 in Science Translational Medicine...
Ribonuclease II preserves chloroplast RNA homeostasis by increasing mRNA decay rates, and cooperates with polynucleotide
phosphorylase in 3 «end maturation
PULLMAN — Three WSU researchers recently received a grant to figure out
how phosphorylase, an enzyme that plants and animals both have, works with photosynthesis.
Unlike the
animal phosphorylase, the plant enzyme has an extra peptide, or building block of protein, that, until recently, didn't appear to do much.
Abnormal Physiological and Molecular Mutant Phenotypes Link Chloroplast
Polynucleotide Phosphorylase to the Phosphorus Deprivation Response in Arabidopsis
Research has shown that cloves accomplish this by blocking the action of
glycogen phosphorylase, which releases glucose into the blood from the liver and the muscles.
Selectivity of the therapeutic approach is achieved by producing an enzyme called E. coli purine
nucleoside phosphorylase (PNP) directly within tumor cells and using the enzyme to generate novel chemotherapy in the tumor mass itself.
The report (1)-- from a group led by UCLA's Dr. Michael Teitell, and including graduate student Carla Koehler, Newcastle University's Dr. Robert Lightowlers, and others — identified and provided initial characterization of
polynucleotide phosphorylase (PNPase) as a mammalian - specific system for the mitochondrial import of nuclear - encoded RNA.
She also isolated and described angiotensin (a hormone that regulates blood pressure),
phosphorylase (a critical enzyme involved in conversion of carbohydrates to energy), and serotonin (a molecule involved in many processes, including pain, sleep, and psychological function).
Polyadenylation in Arabidopsis and Chlamydomonas organelles: The input of nucleotidyltransferases, poly (A)- polymerases and polynucleotide phosphorylase
Phosphorylase has been studied extensively in both plants and animals.
Light microscopic evaluation of histological and histochemical stains and reactions was performed according to standard protocols [20] and included hematoxylin and eosin, modified Gomori trichrome, periodic acid Schiff,
phosphorylase, esterase, myofibrillar ATPase reaction at preincubation pH of 9.8, 4.5, and 4.3, reduced nicotinamide adenine dinucleotide - tetrazolium reductase, succinic dehydrogenase, acid phosphatase, and oil red O.