Sentences with phrase «phosphorylation cause»

Abnormal Krebs cycle and / or oxidative phosphorylation cause (s) not only glucose hypometabolism but also the increased generation of reactive oxygen species (ROS), oxidative damage, and programmed cell death such as apoptosis.

Not exact matches

Adenosine 3», 5» - monophosphate at a concentration of 5 x 10 - 7 mole per liter causes a 400 percent increase in the rate of phosphorylation of histone catalyzed by a partially purified enzyme preparation from rabbit brain.

Cellular transfection of β - arrestin 2 caused cytosolic retention of JNK3 and enhanced JNK3 phosphorylation stimulated by ASK1.

In this study, by using a systemic mtEF4 gene knockout mouse model, researchers found that mtEF4 knockout damages the oxidative phosphorylation function in germ cells of male mice, thus causing male sterility.

Mice with the PER1 phosphorylation defects ate earlier than other mice — causing them to wake up and snack before their sleep cycle was over — and ate more food throughout their normal waking period.

«We realized that studying the lithium response could be used as a «molecular can - opener» to unravel the molecular pathway of this complex disorder, that turns out not to be caused by a defect in a gene, but rather by the posttranslational regulation (phosphorylation) of the product of a gene — in this case, CRMP2, an intracellular protein that regulates neural networks,» added Snyder.

This discovery provided the physiological basis for subsequent development of fMRI and caused researchers to reconsider the dogma that brain uses oxidative phosphorylation exclusively to fuel its functional activities.

LysoPCs induce Hck - and PKCδ - mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils.

p38 inhibitor (SB203580) caused a minor reduction in the ActD - induced increase in the expression and phosphorylation of p53 in the 293T and Hepa - 1c1c7 cells, but not in the 293 and HepG2 cells.

ActD caused AKT phosphorylation at Ser473, indicating full activation of AKT.

The first task was to identify several specific amino acid sites in the region FUS uses to bind with other proteins where the natural enzyme DNA - dependent protein kinase (DNA - PK) causes phosphorylation.

Thus, phosphorylation at this site likely causes steric and electrostatic disruption of this specific Oct4 homodimer - DNA configuration (the PORE homodimer), but not of the MORE homodimer configuration or Oct4 heterodimer complexes.

The high number or reps will also cause the increase of the volume of enzymes which are involved in the oxidative phosphorylation and anaerobic glycolysis mechanisms which help with energy production and increase the amount of sarcoplasmic fluid which is found inside the cells, as well as the fluid that is situated between the cells.

Among the tocotrienols, γ - tocotrienol has also been shown to inhibit AKT phosphorylation, causing a reduction in NFκB activity induced by carcinogens, growth factors, and several inflammatory stimuli.1 5

What, then, causes the phosphorylation of tau?