Sentences with phrase «phosphorylation changes»

In conclusion, the proteomic approach revealed that cellular stretching induced specific phosphorylation changes in chondrosarcoma cells.

Because a majority of tumors exhibit phosphorylation changes at some point in their development, his lab looked specifically at protein phosphorylation in vesicles.

Not exact matches

Analysis of signaling pathways that were affected pointed to changes in mitochondrial function and oxidative phosphorylation, consistent with a number of studies showing perturbations of these pathways in neurodegenerative disorders.

One way for that to happen is through changes in gene expression, but changes in phosphorylation are equally effective,» explains Beltrao.

«Rissman's prior work demonstrated that CRF and its receptors are integrally involved in changes in another AD hallmark, tau phosphorylation,» said William Mobley, MD, PhD, chair of the Department of Neurosciences and interim co-director of the Alzheimer's Disease Cooperative Study at UC San Diego.

A molecular examination showed that the protein elF2 had undergone phosphorylation (a phosphate group had been added to it, changing its action), leading to several processes, including elevated expression of the RNA on another protein, ATF4.

A major component of the study was a comprehensive analysis of the «phosphoproteome» of prostate cancer tumors and cells, revealing changes in the phosphorylation states of cellular proteins.

«Pin1 changes protein shape through proline - directed phosphorylation, which is a major control mechanism for disease,» explains co-senior author Kun Ping Lu, MD, PhD, Director of Translational Therapeutics in the Cancer Research Institute at BIDMC and Professor of Medicine at Harvard Medical School who co-discovered the enzyme in 1996.

Proper transfer of V1 complexes or subunits from the membrane to the cytoplasm and back appears to require not only phosphorylation events, conformational changes in the V1VO holoenzyme, the V1 complex and the V1 subunit C, but also the temporary interaction with protein kinase A, cytoskeletal elements, the heterotrimeric protein complex RAVE and the glycolytic enzyme aldolase.

We have used systematic molecular bioengineering of the meningococcal LPS through deletion of enzymes involved in LPS biosynthesis in combination with induction of LPS modifying enzymes (for example the deacylase PagL) to yield a variety of novel LPS mutant strains with changes in both lipid A acylation and phosphorylation.

Afferent regulation of chicken auditory brainstem neurons: Rapid changes in phosphorylation of elongation factor 2.

As seen in in vitro co-culture studies, EphA2, EphB2 and EphB4 phosphorylation was reduced in whole tumour lysates of Tie2PEKO animals, independently of changes in gene expression (Supplementary Fig. 10).

Phosphorylation of tumor necrosis factor receptor CD120a (p55) by p42 mapk / erk2 induces changes in its subcellular localization.

To define the signaling changes resulting from each genotype, we isolated naive CD8 + T cells from mice deficient in DGKζ, Cbl - b, or both in DKO; stimulated the cells through their TCRs; and evaluated phosphorylation of Erk and phosphorylation and degradation of IκBα.

Alterations in ΔFV0.1 in the present study are parallel to similar changes in sensitivity to G6P (ΔA0.5), indicating that phosphorylation / dephosphorylation - dependent mechanisms are involved in the changes of FV0.1.

In lab cultures of human and yeast cells, the scientists stopped the harmful clumping of FUS proteins by exposing them to phosphorylation, a process that makes precise changes to the amino acid building blocks of proteins, increasing their negative electric charge.

Meanwhile, computational modeling of the effect of the phosphorylation in the structure of the protein, led by co-author Jeetain Mittal at Lehigh, showed that the change in electric charge is what led to the difference in the proteins» likelihood of aggregating.

Members of the vanilloid receptor family (TRPV) are activated by a diverse range of stimuli, including heat, protons, lipids, phorbols, phosphorylation, changes in extracellular osmolarity and / or pressure, and depletion of intracellular Ca2 + stores.

Electron microscopy showed dose dependent mitochondrial changes following indomethacin administration consistent with uncoupling of oxidative phosphorylation (or inhibition of electron transport) which were indistinguishable from those seen with the uncoupler dinitrophenol.

Electron microscopy shows dose dependent mitochondrial changes that are indicative of uncoupling of oxidative phosphorylation or inhibition of electron transport.

The discordant mTOR - p70S6K phosphorylation with protein only and protein feedings with alcohol is not unprecedented given we [8] and others [43] have shown that mTOR - S6K phosphorylation often parallels changes in MPS but does not always reflect either the magnitude or duration of the increased MPS signal in humans.

The lack of change in 4E - BP1Thr37 / 46 phosphorylation following exercise and between treatments contrasts previous findings in rodents [18], [20], [28].