Sentences with phrase «phosphorylation sites»
"Phosphorylation sites" refers to specific locations on proteins where a chemical modification called phosphorylation can occur. During phosphorylation, a phosphate molecule is added to the protein, which can change its structure and function, allowing it to carry out various cellular processes. Full definition
Characterization of phosphorylation sites in the cytoplasmic domain of the 300 kDa mannose -6-phosphate receptor
biochemj.org
For his Ph.D, he characterized the evolutionary dynamics of phosphorylation sites for functional phospho - proteomics and to understand the evolution of phosphorylation - based cell signaling.
Zhang, Y. and Wolf - Yadlin, A. and Ross, P. L. and Pappin, D. J. and Rush, J. and Lauffenburger, D. A. and White, F. M. (2005) Time - resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Panda and his colleagues hypothesize that normally, PER1 and PER2 are kept synchronized since they have identical phosphorylation sites — they are turned on and off at the same times, keeping sleep and eating cycles aligned.
«Our study identified four previously unknown phosphorylation sites in a LINK - A regulated signaling pathway,» said Lin.
These studies are utilizing phosphorylation site - specific antibodies as well as Rab11 - FIP mutants to define defects in trafficking and polarity.
To get to the bottom of the dispute, Wang genetically engineered mice to eliminate three key phosphorylation sites in Mdmx.
They mapped the spatial relationship of 3,509 proteins and 225 distinct phosphorylation sites.
Despite evidence for divergence at several loci, certain 1a characteristics were preserved including the length of the alternative reading frame / F protein (ARF / F) gene, and a subtype 1a - specific phosphorylation site in NS5A (S349).
Point mutations of a putative phosphorylation site can specifically abrogate transcriptional activity of a specific homodimer assembly, with little effect on other configurations.
Their collaborators at the Uniformed Services University, including co-lead author Zachary Monahan and co-corresponding author Frank Shewmaker, continued the work by confirming these and more phosphorylation sites in FUS derived from human cells.
Yellow circles indicate tyrosine phosphorylation sites in the activated Eph receptor.
For example, our past work showed that two conserved tyrosine phosphorylation sites in the juxtamembrane segment of the Eph receptors not only mediate association with binding partners but also regulate receptor kinase activity.
In mice with a genetic deletion of DARPP - 32 or with point mutations in phosphorylation sites of DARPP - 32, the effects of D - amphetamine, LSD, and PCP on two behavioral parameters — sensorimotor gating and repetitive movements — were strongly attenuated.
Using experimental and computational methods, the researchers reconstructed the evolutionary history of phosphorylation sites — the modifications that can control proteins — in 18 different single - celled species.
The group found that most of the phosphorylation sites had come about relatively recently in evolution, indicating that they are part of what make the species different — and a major contributor to evolutionary diversity.
Hund's team identified a phosphorylation site (Serine 571) on the voltage-gated sodium channel targeted by CaM kinase II that serves as a switch for inappropriate «late» sodium influx.
The sequence similarity between MAD - 3 and pp40 includes a casein kinase II and consensus tyrosine phosphorylation site, as well as five repeats of a sequence found in the human erythrocyte protein ankyrin.
So they bred mice to lack the mouse period genes, and added in a human PER1 or PER2 with a mutation in the phosphorylation site.
As most Cdk1 targets in the cell contain clusters of multiple sites, the regulation of cell cycle switch - points by Cdk1 might prove to be far more complex than generally anticipated, and it is possible that beneath seemingly random constellations of phosphorylation sites, an intricate signal processing logic is hidden.
We have identified tyrosine and serine / threonine phosphorylation sites of Eph receptors and ephrins using mass spectrometry and investigated the signaling role of these phosphorylation sites.
Tyrosine phosphorylation sites (yellow circles) promote Eph kinase activity and also provide binding sites for signaling proteins containing SH2 domains.