Featured on the cover of Developmental Cell, a paper by OIST researchers revealed the mechanistic link between
photoreceptor cell degeneration and defects in protein transport.
Not exact matches
PRA is caused by the
degeneration of the
photoreceptor cells, rods and cones, which are needed for dark and day light vision, respectively.
«If we could perhaps modulate these pathways and prolong survival of
photoreceptor cells, we might be able to delay any further
degeneration even when intervening at these later stages of disease.»
«By putting in healthy
cells, we can basically stop and prevent the
degeneration of the
photoreceptors,» says Sally Temple, the co-founder and scientific director of the Neural Stem
Cell Institute in Rensselaer, N.Y.
The condition is hereditary or age - related, and causes
degeneration of the
photoreceptors — light - sensitive
cells in the retina — leading to blindness.
«Many retinal diseases are manifested by the
degeneration of
photoreceptor cells.»
However, both Goldberg and Albini agreed there is no evidence that this kind of therapy could have treated the patients» sight problems even if carried out correctly and only sparse evidence that adipose
cells can differentiate into retinal pigment epithelium or
photoreceptor cells, which play a critical role in macular
degeneration.
0 Research ArticleRETINAL DISEASES Human ESC — derived retinal epithelial
cell sheets potentiate rescue of
photoreceptor cell loss in rats with retinal
degeneration Karim Ben M'Barek 1,2,3, Walter Habeler1, 2,3, Alexandra Plancheron1, 2,3,
In retinal diseases such as age - related macular
degeneration, for example,
photoreceptor cells that absorb light signals are damaged or dead.
Lanza's team figured out how to coax stem
cells taken from human embryos into becoming the RPE
cells that die off along with
photoreceptors in macular
degeneration, and in 2011 the team began injecting these manufactured
cells into patients» eyes.
These retinal
cells are the type that are killed off in macular
degeneration, eventually leading to the death of
photoreceptors, and the gradual loss of central vision.
ERG abnormalities are evident by 5 — 6 weeks of age and
cell degeneration is present by 4 months, suggesting the mutant protein has a toxic gain of function that severely compromises the early stage of development of the
photoreceptors.