Sentences with phrase «photoreceptor cell function»

The receptor also regulates DHA retention and conservation in cells in the eye and is necessary for photoreceptor cell function.

Not exact matches

He suspects that transplanted cells are actually restoring the function of «dormant» photoreceptors.

The retinal pigment epithelium (RPE) is a single layer of cells that accomplishes multiple functions, such as providing survival molecules that prevent photoreceptors from dying.

The six previously known fly rhodopsins account for the full function of photoreceptor cells in the fly's eyes, so although the fruit fly genome contained the sequence of a seventh rhodopsin, the role of Rh7 was unclear.

The RPE is a single layer of cells lining the back of the retina that is vital to the functioning of the retinal photoreceptor cells, and thus vision itself.

With age, our eyes accumulate waste in retinal pigment epithelium (RPE), which supports the life and function of photoreceptors (light sensitive cells in the eye); in advanced stages, RPE and photoreceptors die.

One can imagine that loss of function of any of the gene products along this complex pathway could lead to severe consequences for the survival of the photoreceptor (PR) cells in the eye.

Of note, while vision rescue requires preservation of some functional photoreceptors, the mere presence of photoreceptor cells in the ONL of transplanted RCS rats does not assure function [61].

It is likely that those cells would then support the function of the very important photoreceptor cells in the retina.

The retinal pigment epithelium (RPE) is a monolayer of cells, residing at the back of the eye between Bruch's membrane and the retina, which is essential for photoreceptor function and survival.

As a monolayer of cells critical to photoreceptor function and survival, the RPE is an ideally accessible target for cellular therapy.

Although known to have neuronal cell functions STK38L has not previously been associated with abnormal photoreceptor function; being associated with such a disease in dogs establishes this gene as a potential candidate for similar diseases in other species, including man.

The gene product's precise role is not currently understood but it is thought to anchor regulatory complexes at the photoreceptor connecting cilium, which acts as a bridge between the inner and outer segments of photoreceptor cells [43] as well as having functions in disk morphogenesis [42] and in the structure of the ciliary axoneme [44].

ERG abnormalities are evident by 5 — 6 weeks of age and cell degeneration is present by 4 months, suggesting the mutant protein has a toxic gain of function that severely compromises the early stage of development of the photoreceptors.

Whereas the genes implicated in early - onset diseases are those necessary for the correct development of photoreceptors the genes associated with later - onset forms of disease are those necessary for the long - term maintenance and function of these cells.