Sentences with phrase «photoreceptor loss»

However, based on the available data, the presence of autofluorescent material does not provide us with specific clues about the cellular and molecular disease mechanisms resulting in photoreceptor loss and retinal degeneration.

(2006) Müller Cell Activation Correlates with Photoreceptor Loss in DBA / 2 Mice (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1562).

Animals received unilateral subretinal injections of hNPC or medium alone at an age preceding major photoreceptor loss.

In order to study rescue effects following surgery, donor cells were introduced at P21, an age preceding major onset of photoreceptor loss.

More recently, her lab started working on the mechanisms that link oxidative stress and photoreceptor loss and dysfunction, with the goal of identifying ways to target the underlying processes to prevent photoreceptor and RPE loss in dry AMD.

After initiating photoreceptor loss in the fish retinas, the researchers monitored the immune system's response by tracking the activity of three types of fluorescently labeled immune cells in and around the eye: neutrophils, microglia and peripheral macrophages.

«The goal is to halt the rate of photoreceptor loss,» says Robert Lanza, chief scientist at Advanced Cell Technology (ACT) of Worcester, Massachusetts, the company that has been developing the treatment since first turning hESCs into RPEs in 2004.

Not exact matches

«The loss of photoreceptor cells affects virtually all of us.»

«In the best - case scenario, we thought we could hopefully prevent the loss of vision in these patients,» he says, because RPE cells are known to help maintain existing photoreceptors, in part by digesting the cellular debris that they shed.

As RPEs help to maintain and support adjacent photoreceptor cells which capture light, their loss leads to blindness.

The answer, says a report in the 1 November issue of Science, lies in the genetic makeup of persons suffering from a partial loss of photoreceptors.

Most causes of untreatable blindness occur due to loss of the millions of light sensitive photoreceptor cells that line the retina, similar to the pixels in a digital camera.

Functional damage to these photoreceptors, or pathological loss of the cells that bear them, results in inability to register light impinging on the retina — and is responsible for various types of visual impairment and certain forms of congenital blindness.

«This study for the first time shows increased expression of IL - 33 in AMD and further demonstrates a role for glia - derived IL - 33 in the accumulation of myeloid cells in the outer retina, loss of photoreceptors, and functional impairment of the retina in preclinical models of retina stress,» the authors note.

Its loss destroys all photoreceptor function.

AMD, a major cause of irreversible vision loss in the elderly, results from death of cells critical for vision: RPE and photoreceptor cells.

0 Research ArticleRETINAL DISEASES Human ESC — derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration Karim Ben M'Barek 1,2,3, Walter Habeler1, 2,3, Alexandra Plancheron1, 2,3,

In the absence of myosin VI, the amplitudes of the a - and b - waves of the electroretinogram were reduced, although there was not photoreceptor cell loss and retinal anatomy appeared normal.

One can imagine that loss of function of any of the gene products along this complex pathway could lead to severe consequences for the survival of the photoreceptor (PR) cells in the eye.

This defect produces a debris zone between photoreceptors and RPE, with subsequent loss of the photoreceptors themselves.

Second Sight's retinal prosthesis is currently approved only for patients with inherited retinal disorders (IRD), formerly known as retinitis pigmentosa, a group of genetic diseases characterized by a loss of photoreceptors.

These retinal cells are the type that are killed off in macular degeneration, eventually leading to the death of photoreceptors, and the gradual loss of central vision.

This Clinical Statement provides recommendations for patients with inherited retinal degenerations, which comprise a wide range of genetically and phenotypically heterogeneous diseases associated with progressive loss of photoreceptor function and visual loss.

This condition, also known as Achromatopsia, or color blindness, is characterized by cone photoreceptor dysfunction, severely reduced visual acuity or complete vision loss during daylight hours, and photophobia.

The retina is normal when viewed with an ophthalmoscope, but there is a loss of photoreceptor activity as evidenced by a diminished electroretinogram (ERG).

In general, PRAs are characterized by initial loss of rod photoreceptor function followed by that of the cones and for this reason night blindness is the first significant clinical sign for most dogs affected with PRA.

Small islands of relatively normal appearing retina (B1) are surrounded by severely degenerated retina characterized by the loss of photoreceptors and ONL thinning (B2).

(D) Accumulation of autofluorescent material (green) within the RPE can also be seen in a well preserved region of a 13 - year old Stage - 2 affected retina (arrow), possibly indicating that increased autofluorescence may precede loss of photoreceptors.

Electroretinography revealed a gradual loss of both rod and cone photoreceptor - mediated function in Stages 2 and 3 of the disease.

Most valuable was the tissue sample from a 15 - year old Stage - 3 retina with distinct regions of varying disease severity (Fig. 4B): Small islands of relatively normal appearing retina (Fig. 4B1) were surrounded by large areas of advanced retinal degeneration with loss of both rod and cone photoreceptors (Fig. 4B2).

(C) At the transition between relatively well preserved and completely absent (*) retinal architecture, loss of photoreceptors (cones are labeled red with hCAR antibody) is associated with accumulation of autofluorescent material (green) in the subretinal space and within the RPE (arrows).