Light perception takes place in the cone and rod photoreceptor cells of the retina, a structure at the back of the eye, through a set of proteins denominated
phototransduction cascade proteins.
Any defect involved in these processes
of phototransduction and transmission in the retina lead to visual impairment.
They have a very specialized apical membrane structures called the outer segment (OS), in
which phototransduction molecules function.
Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and the guanylate cyclase — which
mediate phototransduction, the process of converting light into an electrical signal.
Moreover, they found that a drug that blocks those channels stopped hydras responding to light, showing they are used
for phototransduction.
To find the new mutation, the scientists looked at five key genes that play a role
in phototransduction, or the process by which light signals are transmitted through the eye to the brain.
This causes another type of protein, an ion channel, to generate an electrical signal along nerves connecting the eye to the brain — a process
called phototransduction.
The hydra is the most primitive animal with functioning opsins, so the team concludes that it represents «the very origin of
animal phototransduction», which was incorporated into more complex eyes as they evolved.
CITATION: «De Novo Transcriptomics Reveal
Distinct Phototransduction Signaling Components in the Retina and Skin of a Color - Changing Vertebrate, the Hogfish (Lachnolaimus Maximus),» Lorian E. Schweikert, Robert R. Fitak and Sönke Johnsen.
Dr. Zuker is known for his work in sensory neuroscience, including mechanisms
of phototransduction, mechanotransduction, and more recently taste.
Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and the guanylate cyclase - which
mediate phototransduction, the process of converting light into an electrical signal.
In the current study, the same group presents a detailed analysis on the evolution of the main effector of
the phototransduction cascade, the PDE6 enzyme.