They identified 6,479 regions of interest in assessing a possible correlation between
phthalate metabolite exposure and DNA methylation.
Of the 6,479 regions examined, 131 were associated with at least one of
the phthalate metabolites, he reports.
Most of
the phthalate metabolites were associated with a shorter AGD, however, not all associations reached significance.
Analyzes of the mothers urine, identified
all phthalate metabolites in all samples.
Eighty percent of the infants born before 37 week and 30 percent of the full - term infants had levels of four
phthalate metabolites in their urine that exceeded adult guidelines, based on hormone effects, set by the European Food Safety Authority.
In addition, only pubertal boys had lower IGF - 1 concentrations, which were also related to various urinary
phthalate metabolites.
Gender and racial / ethnic differences in the associations of urinary
phthalate metabolites with markers of diabetes risk: National Health and Nutrition Examination Survey 2001 — 2008
Pubertal girls were affected by higher glucose levels during fasting, which was associated with various
phthalate metabolites.
A dose - dependent positive relationship was noticed between urinary
phthalate metabolites and parameters of glucose metabolism (fasting glucose and insulin resistance) in both sexes (180).
The researcher concludes: «These changes in male infants, associated with prenatal exposure to some of the same
phthalate metabolites that cause similar alterations in male rodents, suggest that commonly used phthalates may undervirilize humans as well...»
Not exact matches
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They measured 17
metabolites from 8 different
phthalate parent compounds in that sample, then performed DNA methylation analyses on sperm cells to examine statistical associations.
Among boys ages 6 - 12, increased concentrations of
metabolites of a
phthalate called di -(2 - ethylhexyl)
phthalate, or DEHP, was linked to a 24 to 34.1 percent drop in testosterone levels.
The women reported their use of feminine hygiene products like tampons, pads, vaginal douches, feminine spray, feminine powder and feminine wipes and had provided urine samples that were measured for
metabolites of
phthalates.
Sweat also contains certain
phthalate compounds and their
metabolites [9], none of which we want.
And one of those
metabolites is MEHP, the
phthalate most closely tied to small penis size in infant boys.