Pangenomic Definition of Prokaryotic Species and
the Phylogenetic Structure of Prochlorococcus spp. — Mikhail A. Moldovan — Frontiers in Microbiology
We identify ancient
phylogenetic structure within African haplogroups and resolve a long - standing ambiguity deep within the tree.
Subcloncal
phylogenetic structures in cancer revealed by ultra-deep sequencing had two aspects that appealed strongly to me — the use of massively parallel sequencing to study leukemia, and a formalized algorithm to distinguish true variants from false - positives.
Not exact matches
Furthermore, researchers did a suite of model - based analyses of population
structure and
phylogenetic reconstruction.
Today, many ecological and evolutionary studies depend on a wide range of molecular tools to infer
phylogenetic relationships, uncover population
structure within species, and track quantitative traits.
The
phylogenetic position of the cephalochordate amphioxus, together with its relatively simple and evolutionarily conserved morphology and genome
structure, has led to its use as a model for studies of animal evolution, with a special focus on the origin of deuterostomes, chordates, and vertebrates.
The
phylogenetic and geographic
structure of Y - chromosome haplogroup R1a.
The projects will provide training in: current molecular biology techniques (including RNA interference, genetic transformation, analyses of gene expression); cell biology techniques (cell culturing, cell transfections, imaging); protein biochemistry (2D electrophoresis, protein functional analyses); and bioinformatics (
structure predictions,
phylogenetic analyses; molecular interactions).
In this project, I applied NASP for single nucleotide polymorphism (SNP) identification and characterization, and used FigTree and PHYLOBar for
phylogenetic analysis and visualization.The NASP method differs from other published SNP pipelines in terms of supported short - read aligners and SNP callers, the ability to call both monomorphic and polymorphic sites, and the ability to integrate the results from multiple SNP callers and identify the consensus set of SNPs that define the population
structure.
He has particular interests in (1) the use of ancient DNA methods to document changes in genetic variation through time and
phylogenetic relationships of extinct or endangered organisms (especially of the recently extinct Hawaiian avifauna); (2) the use of highly variable genetic markers to measure genetic
structure and relatedness, and to ascertain mating systems, in natural populations, and (3) the use of genetics to study the evolutionary interactions between hosts, vectors and infectious disease organisms (e.g., major projects on introduced avian malaria in native Hawaiian birds and invasive chytrid fungus in amphibians).