«Effect of sustained
physiologic hyperinsulinemia and hyperglycemia on insulin secretion and insulin sensitivity in man» Diabetologia Oct1994, Vol37, Iss 10, 1025 - 1035 Del Prato S.
Specifically, chronic hyperglycemia and
hyperinsulinemia induced by high glycemic load carbohydrates may elicit a number of hormonal and
physiologic changes that promote insulin resistance (71,77,78).