The stress - physiological pathway: from adolescent stressor to
physiological dysregulation in multiple systems
B. Affective and
Physiological Dysregulation.
The index represents the sum of
physiological dysregulations in the body of an individual in response to chronic stressful situation prior to onset of medical illnesses, and is measured by a combination of biomarkers of health such as adiposity, blood pressure and plasma glucose level.
Not exact matches
For example, Hofer (1987, 1994) examined
physiological regulation in rat babies (who are much less social than humans) and has demonstrated that separation from mother causes
dysregulation in multiple
physiological systems like breathing, heart rate, hormones.
An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of
physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular
dysregulation in human disease.
Numerous studies suggest that maternal stress experienced in utero influences programming of key
physiological systems that contribute to childhood disease57 and that nonoptimal early childhood environments and caregiving experiences also influence these processes.58 - 61 Specifically, emerging data implicate the disruptive impact of stress on the HPA, autonomic, neuroendocrine, and immune systems.1, 3,7,57,62 Disruptions of these stress regulatory systems may, in turn, be linked to immune
dysregulation, increasing vulnerability to the development of diseases such as asthma.
The chapter proposes that the risk for both
physiological and behavioral
dysregulation as a result of poor early care in infancy constitutes a hidden trauma.
McEwen has characterized these accumulated risks as «allostatic load:» As
physiological systems fluctuate to meet the demands posed by a stressful environment,
physiological costs of chronic exposure to recurring or heightened neural or neuroendocrine responses to repeated or chronic stress accumulate, resulting in interacting
dysregulations in multiple
physiological systems (10).
An emerging perspective focuses on the accumulation of interacting
dysregulations in multiple
physiological systems that compromise the systems» abilities to respond flexibly to stressful circumstances.
Correspondence between
physiological and self - report measures of emotion
dysregulation: A longitudinal investigation of youth with and without psychopathology
Correspondence between
physiological and self - report measures of emotion
dysregulation: a longitudinal investigation of youth with and without psychopathology.
Physiological measures of emotion
dysregulation: Investigating the development of affective disorders
Physiological markers of emotion and behavior
dysregulation in externalizing psychopathology