To understand and control their potential for differentiation in vitro is to offer unprecedented opportunities for regenerative medicine and for advancing the study
of physiopathological mechanisms and the quest for therapeutic strategies.
They are broadly expressed in excitable and non-excitable cells, and have in turn been implicated in a large spectrum of
physiopathological processes, ranging from the regulation of neuronal excitability, respiratory and cardiac function to the control of cell volume, hormone secretion and cell proliferation.
Real time magnetic resonance imaging
for physiopathological assessments, for instance in pulmonary hypertension.
After that, focusing on cancer diseases, we provide new insights into the potential role of these innate CD8 (+) T cells in
a physiopathological context in humans.
Due to
these physiopathological complexity and heterogeneously, one of the major requirements for a successful therapy is the design of a multifunctional nanomedicines that is able to selectively attack specific markers from tumor and stroma cells.