Sentences with phrase «pig models»
The technology also has the potential to knock out specific genes to create pig models of human diseases.
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Her research involves preclinical immunology and efficacy of vaccines against H5N1 pandemic influenza, malaria, and Mycobacterium tuberculosis using mouse, ferret and guinea pig models.
We will develop in - house pig models of neonate infants to improve the vaccination of this population.
As a postdoc at the University of Iowa Carver College of Medicine in Iowa City, Rogers used the pig model to better understand the genetic underpinnings of cystic fibrosis — research that earned him a first - author publication in Science in the 26 September 2008 issue (p. 1837).
The next step is a study in a pig model,» says Professor Phillipson.
Using a pig model may help other scientists more effectively test treatments for colon cancer, type 2 diabetes and other chronic diseases.
We show that a pig model may be an alternative that can help lead to better treatments and food - based prevention and therapeutic strategies.»
«Using a pig model to study chronic diseases may help minimize drug failure rate.»
Using genetic engineering technology, a team of scientists has established a pig model of Huntington's disease (HD), an inherited neurodegenerative disease.
«We think the pig model will fill an important gap,» says co-senior author Shihua Li, M.D, professor of human genetics at Emory University School of Medicine.
The pig model of HD also more closely matches the symptoms of the human disease.
«Pig model of Huntington's offers advantages for testing treatments: Large animal model of neurodegeneration similar to human.»
The researchers chose the pig model because pig heart size and physiology is very similar to humans.
So similar are the two that researchers at the University of Georgia's Regenerative Bioscience Center have developed the first U.S. pig model for stroke treatments, which will provide essential preclinical data and speed the drug discovery process.
The careful choice of the pig model as well as use of readily available microbubbles and ultrasound was instrumental in studies moving to clinical trials.
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The pig model of HD, published yesterday in Cell, also more closely matches the symptoms of the human disease.
Researchers have used CRISPR to develop a pig model of Huntington's disease that better mimics how the disease progresses in humans.
Effect of Human Adipose Derived Stem Cells on Scar Formation and Remodeling in a Pig Model: A Pilot Study (July 16, 2012) in Results and Conclusions.
This pig model attempts to mimic the clinical situation of human LPR more closely by challenging healthy, uninjured laryngeal epithelium.
It's much more believable than the pigs model, which (I have to admit) was a bit contrived from the standpoint of actual animal husbandry.
I liked the pig model, but here is an alternative:
Not exact matches
They plan to use their organizations as guinea pigs to seed the initial usage, technology development, and business model, and then expand from there.
Under the new reforms, all pig and poultry farms, regardless of size or production model, will be considered «intensive livestock agriculture.»
I was given the exact model Air Fryer as yours for Christmas (w / «Learn to cook instead of pigging on fast food» enclosed w / the card).
He has called actress Rosie O'Donnell a «fat pig» and retweeted an unflattering image of Heidi Cruz, wife of Republican primary opponent Ted Cruz, next to a shot of his own wife, Melania, a retired model, with the caption, «These images are worth a thousand words.»
The researchers then verified the model by shooting at sponges soaked in pig's blood, and measuring the resulting spatter patterns.
The Centers for Enterprise helped get patents on Rogers's processes and «biological material» (the actual herd of pigs); the company licensed the gene - model technology from the university.
In a paper published in the journal Systematic Biology and delivered at the Society for Molecular Biology and Evolution Conference this week, Dr Phillips said biases in models of DNA evolution inflated estimates of when modern mammals, which were once no larger than a guinea pig, diversified and evolved into the animals familiar to us today.
«What we had done for the cystic fibrosis pigs was applicable to other diseases» for which the previous animal models were not sufficient, Rogers says.
Pig brains are remarkably similar to human brains, so they are often used as model systems by neuroscientists.
Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.
A good model system for research is provided by Oesophagostomum dentatum, a roundworm which infects the large intestines of pigs, slowing the animals» growth and leading to significant economic losses.
The SMA model pig was created using a gene therapy approach by knocking down the levels of pig SMN, followed by treatment with human SMN at early and late time points.
Researchers measured blood levels of pig SMN mRNA and human SMN mRNA in a porcine model of SMA longitudinally.
«We are now studying pigs, which turn out to be a very good model for human cystic fibrosis,» Schaffer says.
Organoids are especially useful because no great animal models for CF exist, Kerem says; ferrets and pigs are sometimes used, but «they are expensive and not available to most researchers.»
They have developed a model that is able to predict pig house odours.
Usually, it takes a nose to smell, but now — for the first time — scientists have developed a convincing model able to measure odours from pig farms by means of precise measurements of the content of odorants in the atmosphere.
If the findings of the study are replicated in other animal models, such as pigs, they could have considerable implications for public health, says Oluf Pedersen, professor of genomic medicine at the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen.
«In pigs, the pattern of neurodegeneration is almost the same as in humans, and there have been several treatments tested in mouse models that didn't translate to human.»
Working with Liangxue Lai, the Li lab has generated transgenic — not «knock - in» — pigs that are models for HD.
Compared with non-human primate models, the pigs offer advantages of faster breeding and larger litter sizes, the researchers say.
Now, the same groups have built more elaborate models that paint a detailed picture of how the British countryside was ravaged by the FMD virus, taking into account things such as the location of every farm, the estimated number of pigs, cattle, and sheep each farm contained, as well as exhaustive data about the spread of the disease and the culling process.
«Once the in - vitro validation has been done, the efficacy of these compounds will be tested in pig and mouse models.
Results of their studies in the pig heart attack model that preserved heart muscle in that crucial period are reported in the September 2015 issue of the journal Heart.
The researchers have tested their early warning system in a mouse model and on pig skin.
The pigs showed both movement problems and respiratory difficulties common to human patients, and it is hoped that this model will assist in the creation of new treatments for Huntington's — a genetically inherited and fatal disease which affects tens of thousands of people.
If the marriage of stem cells and CRISPR follows a similar path, it might not be long before pigs have enough Homo sapiens in them not only to grow human hearts, lungs, livers, and kidneys for transplant but also to model human diseases more closely than current lab animals do and to test experimental drugs.
Emory research reports on a pig HD model and on CRISPR / Cas9 gene editing are just part of the wave.