The technology also has the potential to knock out specific genes to create
pig models of human diseases.
Not exact matches
The
pig model of HD also more closely matches the symptoms
of the
human disease.
The
pigs showed both movement problems and respiratory difficulties common to
human patients, and it is hoped that this
model will assist in the creation
of new treatments for Huntington's — a genetically inherited and fatal
disease which affects tens
of thousands
of people.
If the marriage
of stem cells and CRISPR follows a similar path, it might not be long before
pigs have enough Homo sapiens in them not only to grow
human hearts, lungs, livers, and kidneys for transplant but also to
model human diseases more closely than current lab animals do and to test experimental drugs.
The
pig model of HD, published yesterday in Cell, also more closely matches the symptoms
of the
human disease.
Researchers have used CRISPR to develop a
pig model of Huntington's
disease that better mimics how the
disease progresses in
humans.