Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, et
Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide
differentiation of pluripotent
cells to a
cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, et
cell fate, which presents a interest for the replacement of the defective
cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, et
cell population from the patient (the striatal neurons for Huntington's disease, the
cells of the retinal
pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).
Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified
pigment production (a hallmark of melanocyte
differentiation state) and changes in morphological
cell properties.
A gene called Alx3 blocks the
differentiation of
pigment - producing
cells in the skin of the African striped mouse, thus generating the mouse's characteristic light - colored stripes, a new...