Sentences with phrase «pigment epithelial cells»
Meyer et al 2009 [24] have recently shown that iPS cells can be differentiated towards retinal cell types whilst a paper by Buchholz et al 2009 [25] has shown that human iPS cells can be differentiated into retinal pigment epithelial cells which display functionality in vitro.
http://journals.plos.org/
The stem cell approach I am most excited about involves a treatment to replace cells called retinal pigment epithelial cells.
Third place went to Charlie Granger, a PhD candidate in optics, who used adaptive optics technology to show the natural fluorescence of retinal pigment epithelial cells, which form a layer only one cell deep, on the backside of the eye's light - sensitive retina.
The company has turned human embryonic stem cells into retinal pigment epithelial cells, which will be surgically implanted into the eye.
Orientation of actin filaments in teleost retinal pigment epithelial cells, and the effect of the lectin, Concanavalin A, on melanosome motility.
Xeno - Free and Defined Human Embryonic Stem Cell - Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large - Eyed Preclinical Model
In this pilot case, a sheet of retinal pigment epithelial cells was transplanted into a patient.
It results from the death of cells critical for vision: retinal pigment epithelial cells (RPE) and photoreceptor cells.
Oxidative stress renders retinal pigment epithelial cells susceptible to complement - mediated injury.
As you mentioned, in dry AMD we basically have atrophy in the back of the retina in cells that are called retinal pigment epithelial cells.
His recent published work describes the rescued visual function in animals using retinal pigment epithelial cells derived from human embryonic stem cells and a method for deriving stem cells using a single - cell approach that does not harm embryos.
This is a scanning electron microscope image of retinal pigment epithelial cells derived from stem cells.
He and his colleagues will inject into patients» eyes retinal pigment epithelial cells that ACT derived from hES cells.
With the passage of time, patches of retinal pigment epithelial cells may die, resulting in bare spots known as geographic atrophy.
It has been designed for treating the «dry» form of macular degeneration, caused by deposits on the retina gradually killing retinal pigment epithelial cells, which support light - capturing cells.
To test their idea for the dry form, Amir Kashani of the University of Southern California in Los Angeles and his colleagues coated 6 by 4 - millimetre slithers of polymer with retinal pigment epithelial cells they had grown, then transplanted these into four people.
Similar patches have already had some positive results for the «wet» form, in which blood vessels invade and destroy the retinal pigment epithelial cells.
Researchers at the RIKEN Center for Developmental Biology in Kobe plan to generate replacement retinal pigment epithelial cells from iPS cells generated from patients suffering age - related macular degeneration.
The study, which followed four individuals for a year after they were treated with embryonic stem cell - derived retinal pigment epithelial cells for macular degeneration, observed no serious side effects (tumor growth or other unexpected effects) related to the therapy.
The multinational research group utilized a model system where human retinal pigment epithelial cells were infected with Zika virus strain they isolated earlier from fetal brain [T1].
In this pilot study to test the safety of putting iPS - derived cells into humans, the six are all receiving a graft of new retinal pigment epithelial cells, which serve to maintain the eye's light - sensing cells.
Their sight deteriorates from around age 6 when retinal pigment epithelial cells (RPEs) start to die off rapidly, possibly due to a defective gene.
Similar patches and treatments have already been tested against the «wet» form — in which blood vessels invade and destroy the retinal pigment epithelial cells that nourish and support the photoreceptor cells that capture light.
The «dry» form is caused by natural deposits on the retina that gradually kill retinal pigment epithelial cells.
Ten years ago, the team at Advanced Cell Technology announced that it had successfully converted human embryonic stem cells into retinal pigment epithelial cells.
Long - lived cells such as cardiomyocytes, retinal pigmented epithelial cells and neurons are particularly dependent of the efficient function of their lysosomes to prevent the accumulation of damaged macromolecules over their extended lifetimes.
Subsequent single - cell flow cytometric assays linked this shorter G1 phase to the more rapid loading of minichromosome maintenance (MCM) helicase complexes when compared to differentiated cells with longer G1 phases (neural progenitor cells and retinal pigmented epithelial cells).
Long - lived cells such as cardiomyocytes, retinal pigmented epithelial cells and neurons are particularly dependent of the efficient function of their lysosomes to prevent the... >> MORE
Not exact matches
Three years after publishing a groundbreaking paper in which she isolated adult retinal pigment epithelial stem cells, Temple is in preclinical trials with rats.
In AMD, the retinal pigment epithelial (RPE) cells that support the cells in the eye that detect light wear out, and there is also the growth of abnormal, leaky blood vessels below the retina.
Our first results demonstrate our ability to produce retinal precursors (even at a low yield) and mainly Retinal Pigment Epithelial (RPE) cells at a high yield (99 %) from hES and iPS cells.
The degeneration of retinal pigment epithelial (RPE) cells as a consequence of impaired mitochondria has emerged as a key feature of early - stage age - related macular degeneration (AMD).
So far, two major endogenous cell sources for neuronal regeneration have been described: the Müller glia (MG) and retinal pigment epithelial (RPE) cells.
A trial being conducted by Advanced Cell Technology is testing the effectiveness of MA09 - hRPE, human ESCs terminally differentiated into retinal pigment epithelial (RPE) cells, in treating degenerative macular diseases.
Human iPS - RPE are pigmented cuboidal epithelial cells with cytoplasmic polarization.
Meconium is the greenish mix of bile, amniotic fluid, bile pigments, epithelial cells, mucus, blood and other substances found in the first stool of a newborn.