Sentences with phrase «pigment epithelium»
The phrase "pigment epithelium" refers to a layer of cells that produce and contain pigments. These pigments give color to different parts of our body, such as the hair, skin, and eyes. Full definition
It aims at evaluating the tolerance to a hESC - derived retinal pigmented epithelium cell transplantation.
istem.eu
Eye opener: A confocal microscope image of a rat retina after injection of human retinal pigment epithelium cells.
Madalena Pereira (Ader, TUD)-- «Cell - based replacement of retinal pigment epithelium in rodent models of retinal degeneration» (2014)
In approximately 10 percent of patients with macular degeneration, the injury to the retinal pigment epithelium stimulates the choroidal blood vessels to grow up into the RPE and retina — seemingly in an attempt to heal the defects in these layers.
Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).
The treatment, which consists of a layer of human embryonic stem cell - derived retinal pigment epithelium cells on an ultrathin supportive structure, was implanted in the retina of four patients by a USC Roski Eye Institute surgeon.
Other BrightFocus - funded research is studying drugs that stimulate the removal of misfolded protein that is in other cellular garbage, from the retinal pigment epithelium in the sublayer of the retina that we were talking about.
Tetrahydropyridoethers Eliminate Lipofuscin From Retinal Pigment Epithelium of Monkeys U. Schraermeyer , S. Schultheiss , S. Hofmeister and S. Julien Experimental Vitreoretinal Surgery, Institute for Ophthalmic Research, Tubingen, Germany Commercial Relationships: U. Schraermeyer, None; S. Schultheiss, None; S. Hofmeister, None; S. Julien, None.
Twenty - five had ophthalmologic changes: 18 with intraocular abnormalities, including macular chorioretinal atrophy, mottled retinal pigment epithelium, and optic nerve pallor; seven with strabismus or nystagmus without intraocular abnormalities.
From the embryonic stem cells, the researchers produced a type of tissue called retinal pigment epithelium (RPE).
Researchers used stem cells to create retinal pigment epithelium cells, which were transplanted into a patient's retina (left) in an area depicted by the black circle.
A layer of cells called the retinal pigment epithelium (RPE) is essential for supporting and nourishing the retina cells that capture light for vision.
This infolding put the photoreceptors in close proximity to the retinal pigment epithelium, enabling the biochemical recycling of retinoids following light absorption, the attenuation of light that passes through the photoreceptors unabsorbed, and the delivery of oxygen and nutrients from the overlying choroid tissue.
The mutated gene fails to produce RPE65 protein in the retinal pigment epithelium (RPE), a cell layer critical for protecting photoreceptors (rods and cones).
Modified ECO nanoparticles bind to interphotoreceptor retinoid - binding protein (IRBP), which transports them to the target cells in the retinal pigment epithelium (RPE.)
The volunteers, ranging in age from 20 to 88, received injections under their retina of a particular type of eye cell, retinal pigment epithelium (RPE) cells, which were derived from hESCs in the lab.
The retinal pigment epithelium (RPE) is a single layer of cells that accomplishes multiple functions, such as providing survival molecules that prevent photoreceptors from dying.
«Previous studies primarily focused on neurons and the retinal pigment epithelium cells as culprits in degeneration,» said Eroglu, who is also a member of the Duke Institute for Brain Sciences (DIBS).
It first targets a protective lining called the retinal pigment epithelium (RPE), which shuttles nutrients to the photoreceptor cells and is vital for their survival.
Four patients received implants consisting of human embryonic stem cell - derived retinal pigment epithelium (RPE), which support light - sensitive photoreceptor cells critical to vision.
Researchers analyzed three types of adult cells — fibroblasts, retinal pigment epithelium and neural cells.
For example, there have been cases of transplanting retinal pigment epithelium and spine cells from stem cells.
In previous studies, researchers showed that a layer of cells beneath the retina, the retinal pigment epithelium (RPE), ferries glucose from the blood to the retina.
About 10 % of cases are due to a mutation in retinal pigment epithelium 65 (RPE65), a gene that codes for an enzyme that helps retinal cells make rhodopsin.
These included impaired function of retinal pigment epithelium and subsequent blindness due to photoreceptor atrophy and death.
In macular degeneration, clumps of yellowish cellular debris — possibly of retinal origin — gradually accumulate within and beneath the retinal pigment epithelium.
The middle layer is a one - cell - thick sheet known as the retinal pigment epithelium, or RPE.
These vessels supply oxygen and nutrients to the retinal pigment epithelium and photoreceptor cells and carry away waste products.
Ninety percent of patients with age - related macular degeneration never develop new blood vessels and lose vision instead because of atrophy of the retinal pigment epithelium.
In the only ongoing clinical trials involving hESCs, the biotechnology company Advanced Cell Technology (ACT) of Marlborough, Massachusetts, derived a type of cell called retinal pigment epithelium (RPE), which sustains the retina's light - sensing photoreceptors.
The black layer on top of the photoreceptors is retinal pigment epithelium.
This disorder affects retinal pigment epithelium (RPE) cells, the cells critical to the support of the retina's photoreceptor cells, which function in the transmission of messages from the retina to parts of the brain that interpret images.
However, both Goldberg and Albini agreed there is no evidence that this kind of therapy could have treated the patients» sight problems even if carried out correctly and only sparse evidence that adipose cells can differentiate into retinal pigment epithelium or photoreceptor cells, which play a critical role in macular degeneration.
Abbreviations: BrdU, 5 - bromo -2-deoxyuridine; CMZ, ciliary marginal zone; EFTF, eye field transcription factor; ERG, electroretinogram; GABA, gamma - aminobutyric acid; LE, lateral endoderm; N, number of animals or eyes; PNP, posterior neural plate; RPE, retinal pigment epithelium; YFP, yellow fluorescent protein
The retinal neurons rely on their supporting cells, such as retinal pigment epithelium (RPE) cells, to provide them with the fuel to meet their energy needs.
ACT's trial will involve injecting retinal pigment epithelium (RPE) cells, which nurture the retina, into volunteers with the most advanced forms of Stargardt's, in an attempt to replace dying and no longer functioning photoreceptor cells.
The retinal pigment epithelium (RPE) is a layer of cells next to the retina that are metabolically coupled to the retina's photoreceptor neurons.
Wimmers, S., Karl M.O. and Strauss O. Ion Channels in the Retinal Pigment Epithelium.
Three - dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.
People who have the dry type suffer from a progressive thinning of the retinal pigment epithelium, a layer of cells that support and nourish the light - sensing photoreceptors.
Her main research interests lie with investigating key signaling mechanisms in retinal pigment epithelium, with the focus on the pathway mediated by mechanistic target of rapamycin (mTOR), and to identify molecular targets that can potentially be translated into interventional targets for treating chronic ocular diseases such as AMD.
Lipofuscin is a cytologic hallmark of aging in metabolically active postmitotic cells including neurons, cardiac muscle cells, and the retinal pigment epithelium (RPE).
The National Eye Institute has awarded Jackson Laboratory Professor Patsy Nishina, Ph.D., and Associate Professor Gregory Carter, Ph.D., a four - year grant totaling $ 2,414,304 to study diseases of the retinal pigment epithelium (RPE), with the goal of identifying druggable targets for age - related macular degeneration (AMD) and other heritable retinal diseases.