«Previous studies primarily focused
on neurons and the retinal
pigment epithelium cells as culprits in degeneration,» said Eroglu, who is also a member of the Duke Institute for Brain Sciences (DIBS).
Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, et
Cell therapy, as envisaged by the teams of I - Stem, is primarily based
on the identification of experimental protocols that can specifically guide differentiation of pluripotent
cells to a
cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, et
cell fate, which presents a interest for the replacement of the defective
cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, et
cell population from the patient (the striatal neurons for Huntington's disease, the
cells of the retinal
pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).
To further examine the morphology of
cells and the localization of protein expression within the retina, immunohistochemical staining of both paraffin and OCT retinal sections was performed with the following antibodies (Table S1): human cone arrestin (for cone photoreceptors), rhodopsin (for rod photoreceptors), RPE65 (for the retinal
pigment epithelium, RPE), glial fibrillary acidic protein (GFAP, for astrocytes and Müller
cells), glutamine synthetase (for Müller
cells) and G0alpha (for
ON bipolar
cells).