Such a dog will carry the genes for arranging
pigment granules in the nose and other integument to show black, liver, or blue, but nothing at the E locus that allows anything other than tan hairs (or tan with brindle striping).
A black Lab or Boerboel will have a different type of
pigment granule in those hair shafts.
Not exact matches
The shape and chemical composition of these
granules is identical to organelles found
in cells called melanosomes; these being responsible for creating and storing the
pigment melanin.
Melanosomes are intracellular
pigment granules assembled
in the cytoplasm of melanocytes.
Matthew Shawkey, a biologist at the University of Akron
in Ohio who has been working with dinosaur researchers to figure out the colors of those prehistoric beasts, adds that the study should help sway those skeptics who think that the melanosomes detected
in some fossil specimens are really bacteria and not
pigment granules.
Very recently, scientists have been able to detect
pigment - containing
granules, called melanosomes,
in some very early bird fossils, as well as
in their immediate ancestors, the dinosaurs.
And they have made educated guesses about the color of the
pigments in the melanosomes based on the
granules» sizes and shapes.
Close to such depigmented RPE cells, highly
pigmented macrophages identified by CD68 staining were located between Bruch's membrane and the RPE and
in the subretinal space or within the choroid.The total number of lipofuscin
granules was counted
in the cytoplasm of RPE cells from untreated and treated monkeys.
In previous studies using other donor cell types, significant intraretinal migration was not seen [39], [41], nor were pigment granules found in donor cells not originally derived from RPE [39
In previous studies using other donor cell types, significant intraretinal migration was not seen [39], [41], nor were
pigment granules found
in donor cells not originally derived from RPE [39
in donor cells not originally derived from RPE [39].
(B) High power image showing
pigment granule - containing donor cells
in the RPE - L region that are positive for human nuclear marker (arrows).
Another allele, on a different chromosome locus, can cause the arrangement or packed density of
pigment granules to give a brownish color
in areas that are commonly black
in many breeds: nose, dorsal haircoat, etc..
Thus a yellow Lab or red - tan Boerboel will have hair
pigment granules reflecting wavelengths of light
in the red - yellow range of the spectrum.
Before you start arguing, try to see that black and liver (chocolate) are simply modifications of black
pigment granule arrangements
in the cells.
The E locus (let's use E or e to stand for Expression) tells the body whether or not to create and deposit
pigment granules that show up as black or dark (including liver and blue)
in the coat.
«Bhavsar works with dried
granules of
pigment in a very deliberate and precise approach, although it may appear random.