Sentences with phrase «pigmentation variants»

In addition, the data reveal that this was a more genetically diverse population than the central and western European hunter - gatherers living during the same epoch and that they also show pattern of adaptation to high latitude environments, including high frequencies of low pigmentation variants as well as a gene region associated with physical performance, which shows strong continuity into modern - day northern Europeans.

The papers, «Two newly identified genetic determinants of pigmentation in Europeans» and «ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma,» are published today in the online edition of Nature Genetics, at www.nature.com/ng, and will be published in an upcoming print edition of the journal.

The researchers believe that such pigmentation variants also contribute to a higher melanoma risk in the family members who do not carry the mutation.

Previous studies have shown that people with the mutation who also have certain pigmentation variants run an even higher risk of melanoma.

«This suggests that dark - skinned people with this mutation probably don't develop melanoma as often and are therefore not tested for this specific mutation, presumably because they lack the risk - modifying pigmentation variants that increase the risk of melanoma,» says Dr Helgadottir.

Not exact matches

So far, Capra's team has found three functional variants, which are associated with addiction to nicotine, a wider waistline, and skin pigmentation.

The hunter - gatherers also had a high frequency of genetic variants linked to reduced skin pigmentation — a known adaptation to environments with low UV radiation, such as those at high latitude.

We identify previously uncharacterized genes and variants associated with skin pigmentation in ethnically diverse Africans.

Genetically and phenotypically diverse African populations are informative for mapping genetic variants associated with skin pigmentation.

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

Examining ethnically diverse African genomes, we identify variants in or near SLC24A5, MFSD12, DDB1, TMEM138, OCA2, and HERC2 that are significantly associated with skin pigmentation.

These variants arose independently from eye and skin pigmentation — associated variants in non-Africans.

We also identify variants at OCA2 that are correlated with alternative splicing; alleles associated with light pigmentation are correlated with a shorter transcript, which lacks a transmembrane domain.

Several different variants are all uniquely associated with pigmentation near these genes, and variants in these genes have been associated with pigmentation in animals.

Reykjavik, ICELAND, May 18, 2008 — In two papers published today, deCODE scientists and academic colleagues from Europe and the U.S. expand upon the company's recent findings in the genetics of pigmentation traits in people of European descent, and demonstrate that certain of these common variants also confer risk of two types of skin cancer.

Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.

If you do this exercise, you will see, at the very extreme top of the list, variants that are involved in skin pigmentation, in eye color, in hair color.

Depending on the model variant, the seat upholstery is an Alcantara / leather combination or Fine Nappa; on the R8 Spyder a special pigmentation reduces heating from direct sunlight.

Some breeds are prone to unique variants of common pigmentation disorder.