Sentences with phrase «piperaquine resistance»

Recent spread of artemisinin resistance and emerging piperaquine resistance in Southeast Asia show that artemisinin combination therapy, such as dihydroartemisinin - piperaquine, are losing clinical effectiveness, prompting investigation of drug resistance mechanisms and development of strategies to surmount emerging anti-malarial resistance.

Piperaquine resistance was also detected among the same Cambodian samples, consistent with reports of emerging piperaquine resistance in the field.

Interpretation: The exo - E415G SNP and plasmepsin 2 - 3 amplification are markers of piperaquine resistance and dihydroartemisinin - piperaquine failures in Cambodia, and can help monitor the spread of these phenotypes into other countries of the Greater Mekong subregion, and elucidate the mechanism of piperaquine resistance.

Since plasmepsins are involved in the parasite's haemoglobin - to - haemozoin conversion pathway, targeted by related antimalarials, plasmepsin 2 - 3 amplification probably mediates piperaquine resistance.

When multidrug - resistant malaria was detected, researchers were initially handicapped by the lack of a marker for piperaquine resistance; now, they have one, the presence of multiple copies of the plasmepsin 2 gene.

Laboratory tests showed the parasites from dihydroartemisinin - piperaquine failures contained a genetic marker of artemisinin resistance and had a decreased susceptibility to piperaquine, demonstrating that both artemisinin and piperaquine resistance contributed to treatment failures.

When piperaquine resistance emerges as well, treatment fails: Patients get better, but a month later they are sick again.

Not exact matches

New findings from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), confirm dihydroartemisinin - piperaquine, the first - line treatment for Plasmodium falciparum malaria infection in Cambodia, has failed in certain provinces due to parasite resistance to artemisinin and piperaquine.

NIAID researchers and colleagues sought to confirm the presence of piperaquine - resistant infections in Cambodia by comparing the efficacy of dihydroartemisinin - piperaquine treatment in 204 malaria - afflicted participants aged 2 to 65 years from three provinces in Cambodia with varying levels of artemisinin resistance.

Combined with a relatively new quinoline such as piperaquine — to which resistance is still rare — the drug, or a chemical cousin, might form a cheap and safe new combination therapy, says Kelly.