Close to the postrhinal - entorhinal border, entorhinal neurons had stable and discrete multipeaked place fields, predicting the rat's location as accurately as
place cells in the hippocampus.
Place cells in the hippocampus provide a neuronal code for specific locations in space.
«Because the structure we detected was similar in all three experimental conditions, we think that we are picking up the fundamental organization of
place cells in the hippocampus,» said Itskov.
In addition, the Honeycomb Maze enables researchers to study the correlation of spatial navigation performance with the activity of
place cells in the hippocampus where there is a map of an animal's location in space.
Not exact matches
When both mice and people navigate, specialised «
place»
cells in the brain's
hippocampus fire.
The sex - specific differences — the smaller
hippocampus, the presence of fewer nerve
cells, the existence of immune system macrophages
in places they shouldn't be — were also found
in adulthood.
The neurons
in the
hippocampus that store spatial memories (such as the location where you parked your car) are called
place cells.
In the lab, they adapted the standard experimental technique for studying place cells: implanting electrodes directly into a rat's hippocampus and recording from them as the animal runs freely in a large box (see «A sense of place»
In the lab, they adapted the standard experimental technique for studying
place cells: implanting electrodes directly into a rat's
hippocampus and recording from them as the animal runs freely
in a large box (see «A sense of place»
in a large box (see «A sense of
place»).
For their analyses, the scientists specifically colored the
places of origin of axons of so - called pyramidal
cells in the
hippocampus.
To find out if these chemical changes do indeed take
place, the researchers first identified a group of engram
cells in the
hippocampus that, when activated using optogenetic tools, were able to express a memory.
John O'Keefe discovered that certain
cells in a region of the brain called the
hippocampus preferentially fired, or were activated, when an animal was
in a particular environmental location — the first description of «
place cells».
The prize is for discovering «the brain's navigation system»:
place cells,
cells in the
hippocampus which are active whenever a rat is
in a particular
place, and grid
cells,
cells in the entorhinal cortex which are active when the animal is at multiple locations
in a grid pattern.
John O'Keefe, along with John Dostrovsky, discovered
in 1971 that the
hippocampus contains special nerve
cells that are involved
in determining an animal's specific location, which they called
place cells.
In 1978, working with Lynn Nadel, O'Keefe expanded this notion and suggested that in addition to the place cells, the hippocampus might also contain information about direction and distanc
In 1978, working with Lynn Nadel, O'Keefe expanded this notion and suggested that
in addition to the place cells, the hippocampus might also contain information about direction and distanc
in addition to the
place cells, the
hippocampus might also contain information about direction and distance.
Dr. O'Keefe's research identified neurons
in the
hippocampus, called
place cells, which respond selectively to an animal's location.
The idea that the activity of a
place cell is predictive and can be modified by learning and the behavior of other animals may make it easier to conceptualize an all - encompassing framework that ties together the
hippocampus» role
in spatial navigation with its well - established role
in learning and memory formation.