Sentences with phrase «placebo arm»

However, to have the statistical power to confirm trends even in these populations would probably take at least 100 people in both the treatment and placebo arms of the trial.

The study was designed to accumulate 1,612 MACE at which level the study was robustly designed to have 90 % power to detect a 15 % relative risk reduction in MACE between the Vascepa and placebo arms of the study.

Enhanced bone loss was seen in almost all participants in the placebo arm of the study, while no participant in the treatment arm had an appreciable rise in bone loss.

Bone loss was higher in men compared to women in the placebo arm, and the protection against bone loss was higher in men than in women in the treatment arm.

Treatment with zoledronic acid was associated with an eight percent increase in lumbar spine bone marrow density at 12 weeks relative to the placebo arm, with an 11 percent increase at 24 and 48 weeks.

Participants in the placebo arm had a compensatory increase in bone formation, which was an expected result, but bone formation was flat in the treatment arm.

«Such a study would be feasible and ethically justifiable if one excluded certain high - risk groups so that antibiotic treatment would not be withheld from them in the placebo arm.

And a paper published in September by the New England Journal of Medicine reported that a kinase inhibitor made by Rigel Pharmaceuticals of South San Francisco, California, lessened symptoms in up to 67 percent of the patients who received the drug in a 457 - patient study, compared to a 35 percent response in the placebo arm.

Two recent, late - stage clinical trials were stopped because nusinersen, developed by Ionis of Carlsbad, California, and now licensed to Biogen of Cambridge, Massachusetts, was so effective in restoring motor function in children and babies that it was deemed unethical to deny the drug to children in the placebo arms of the trials.

In absolute terms, the overall survival rate at five years was 11 % higher in the ipilimumab arm (65 %) than in the placebo arm (54 %).

The board recommended that the study abandon its placebo arm and now offer treatment to all uninfected participants.

Widely hailed as a «breakthrough» in HIV prevention by public health officials, the studies — one of which dropped its placebo arm today because of the convincing effects of the intervention — add powerful new tools to derail transmission of the virus in the population that accounts for most of the 34 million infections in the world.

The placebo arm received fulvestrant plus placebo.

The 4 - year, $ 44 million study at six sites in sub-Saharan Africa found no difference between the equally sized treatment and placebo arms of the study: There were 130 HIV infections in the women who used PRO 2000 and 123 in those who used a dummy gel.

The foundation's petition calls for a complete halt of the trial of healthy short children, and of the placebo arm of the Turner's syndrome trial.

At the NIH, Love counters that «there is no way to really confirm the effect, particularly if the effects are modest, without a placebo arm in the trial».

Many say that assigning patients to a placebo arm is not ethical, so the TKM - Ebola trial was a so - called single - arm study in which everyone at a treatment center receives the drug and their survival is compared with patients at centers not involved in the trial.

«But human trials of sitagliptin have been limited to date because they have lacked important tools like a placebo arm and allocation concealment (in which researchers do not know what the next treatment allocation will be, further preventing selection bias in testing),» said Loomba.

Nearly 40 % of patients in the active group, vs. 6.3 % in the placebo arm, achieved PASI 100 (completely clear skin) at week 24.

100 % (n = 23) and 87 % (n = 20) achieved titers consistent with protection at day 43 as measured by HAI titers and MN titers, respectively, compared to 0 % in the placebo arm.

Yesterday, away from the conference, it was reported that the placebo arm of a European trial studying the antiretroviral Truvada used as PrEP will be stopped early and volunteers will be offered the antiretroviral because of its observed effectiveness at preventing HIV infection.

Median duration of response had not been reached in the nivolumab plus ipilimumab arm; it was 31.1 months and 18.2 months for the nivolumab plus placebo arm and ipilimumab - alone arm, respectively.

The median OS had not been reached for the nivolumab plus ipilimumab or the nivolumab plus placebo arms.

Methodology: Using the bootstrap sampling method, researchers calculated expected incidence rates by characterizing the age, location and presence of curable sexually transmitted infections among women at their time of enrollment in DREAM, and identified a sample of women with matching characteristics in the placebo arm of The Ring Study.

The two groups were evenly matched with regard to rates of response to induction therapy (44 % complete or partial response in the pemetrexed arm vs. 42 % placebo arm).

Second, this study included a placebo arm.

Throughout the trial, a placebo arm has been used, to help distinguish drug effects from the effects of being in the trial, such as the injection procedure.

All patients underwent induction therapy with four cycles of pemetrexed and cisplatin, and then the pemetrexed arm received pemetrexed continuation maintenance therapy until disease progression while the placebo arm received best supportive care.

The study randomized 539 patients to either a pemetrexed arm (359 patients) or a placebo arm (180 patients).

Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta - carotene and retinol efficacy trial (CARET).