Studies were included if their authors provided the requisite original data, they comprised adult outpatients, they included a medication vs placebo comparison for at least 6 weeks, they did not exclude patients on the basis of
a placebo washout period, and they used the Hamilton Depression Rating Scale (HDRS).
Not exact matches
According to the trial's crossover design, patients with refractory chronic cough of at least eight weeks» duration were randomly assigned initially to either AF - 219 or
placebo treatment twice daily for two weeks, followed by a
washout period, and further followed by crossover to the alternative treatment arm (AF - 219 or
placebo) for an additional two weeks.
After a two - week
washout period, the subjects were crossed over to the tart cherry juice or
placebo group, and the two - week testing period was repeated.
Twelve subjects were subjected to an open - labeled, three - period trial involving sequential oral administration of
placebo, 2g GABA once, and 2g GABA three times / day for 7 days, with a 7 - day
washout between each period.
In this study by Cornelius et al, the reduction in Ham - D - 24 score in the fluoxetine group after detoxification and
washout from 19 to 13, compared with 18 to 16 in the
placebo group, would have added clinical significance if this reduction was associated with a concomitant reduction in current suicidal ideation.