Sentences with phrase «placental cell»

Human placental cell line Jeg - 3 can be readily infected by a circulating strain of Zika virus (left panel) and completely protected by treatment with nanchangmycin (right panel).

The researchers are beginning to use their model to test whether Zika virus, and other pathogens associated with congenital disease, can infect placental cells and / or cross the placental barrier.

In the eight years since then, Markovic and other researchers have discovered some remarkable similarities in how cancer cells and placental cells regulate the immune system.

«Overall, the most important finding is that we identified nanchangmycin as a potent inhibitor of Zika virus entry across all cell types tested, including endothelial and placental cells, which are relevant to how Zika may enter the fetus,» Cherry said.

Both amniocentesis and chorionic villus sampling (another invasive procedure that collects placental cells from within the womb) carry a 1 percent risk of miscarriage.

Additionally, sex differences were recently also described in the transcriptome of human placental cells, demonstrating an influence of fetal sex on placental gene expression in a cell - type dependent manner (186).

In embryos where the mix of normal and abnormal cells was half and half, the researchers observed that the abnormal cells within the embryo were killed off by «apoptosis», or programmed - cell death, even when placental cells retained abnormalities.

It is lethal to frogs and highly toxic to human placental cells, even at one - tenth the recommended dosage.

Not exact matches

For women: zinc stimulates cells division and it can prevent the premature placental abruption.

As early as the first trimester, doctors can take a sample of placental tissue (chorionic villus sampling, or CVS) to detect whether a baby has the genes that would lead to sickle cell anemia or sickle cell trait.

Some scientists study cells, called primary human trophoblasts, that are isolated from placentas obtained after childbirth, but such cells do not divide, can be more difficult to obtain, and are more difficult to genetically manipulate to learn about biochemical pathways that have a role in placental function, Dr. Coyne said.

Her project aims to identify more placental RDGs and determine whether they are also activated in cancer cells, and if so, whether they promote cancer cell invasion.

I'm staring down the eyepiece of a microscope at a tangled but orderly mass of cells, moving the stage past the mucoid connective tissue to examine the concentric circles of a placental vein.

They also observed infection of Hofbauer cells within whole placental tissue.

In addition to answering basic questions about how Zika invades cells, Linhardt's group also wants to come up with a way to block the interactions between the virus and placental sugars, protecting the fetus from harm.

«You'd still have to ration the therapy,» cautions Robert Hariri, chief researcher at Anthrogenesis in Cedar Knolls, New Jersey, which announced this year that it had morphed human placental stem cells into nerve, blood, cartilage, skin, and muscle cells.

The single cell and the two cells resulting from it, have the highest level of cellular plasticity: They are totipotent, which means they can make a full organism, including the extra-embryonic placental tissue.

New research reveals that in pregnant women, Zika virus infection damages certain cells that affect placental formation and function.

Furthermore, herpes simplex virus - 2 (HSV - 2) infection augments placental sensitivity to Zika virus by enhancing the expression of receptors that allow Zika virus to enter cells.

At the moment, prenatal diagnosis for a small number of genetic conditions is usually done from fetal cells that doctors capture from fluid in the womb (amniocentesis) or a snippet of placental tissue (chorionic villus sampling).

The embryo and mother work together to create the placenta; while the trophoblast of the embryo becomes the chorion part of the placenta, the maternal uterine cells and surrounding blood vessels form the maternal placental components (Gilbert, 2003).

Only women who have previously suffered from placental malaria develop substantial levels of protective antibodies that prevent the adhesion of red blood cells to placental CSA.

New research indicates that placental stem cell engraftment may represent an interesting new strategy to treat an enzyme deficiency associated with a lysosomal storage disorder

For AQUA analysis, 2 pairs of slides (containing two cores from different areas of each matching primary and metastatic tumor per patient) or test arrays of cores from FFPE placental tissue and MEL624 cells not overexpressing or overexpressing PD - L1 were concomitantly stained.

They included cloning (somatic cell nuclear transfer, accomplished in many placental mammals), stem cell gametogenesis (has been done in mice), direct engineering of early stage embryos (has been done in several mammals), embryonic stem cell editing, and primordial germ cell (PGC) editing.

[22, 23] To verify antibody specificity, we used small TMAs containing placental and tonsil tissue (known to be positive for PD - L1 expression) and pellets from MEL - 624 cell lines, overexpressing or not overexpressing PD - L1, as previously described.

Chief among them was the finding that in all placental mammals FOXP3 acts through a snippet of DNA called the CNS1 enhancer to trigger the formation of a cohort of Tregs designated «peripheral» (whereas most Tregs are produced in the thymus gland, which sits between the lungs, a subset of the cells act as sentinels suppressing runaway immune responses in the body's peripheral tissues).

Stem cells harvested from amniotic fluid and placental tissue are readily obtainable and have properties of both embryonic and adult stem cells.

He and his colleagues from Brigham and Women's Hospital and Stanford / McGill / UC Berkeley tested amniotic stem cells, derived from placental tissue.

They've also researched exactly which cellular and molecular mechanisms Zika uses to get across the placental barrier and then to infect fetal cells.

A 10 µl of probe hybridization mix was prepared by mixing 100 ng XMRV - SO, 100 ng CEP8 - SA, 1000 ng sonicated human placental DNA, 250 ng human Cot - 1 DNA, and 7 µl LSI / WCP hybridization buffer (Abbott Molecular, Inc.), and was added to each slide over the cell specimen.