Preeclampsia is characterized by poor
placental perfusion and a systemic inflammation that may involve several organ systems, including the cardiovascular system, kidneys, liver, and hematological system (61).
The mechanism mediating this may be secondary to the increased NO bioavailbility enhancing
placental perfusion, as we have previously also reported that maternal treatment with antioxidants can enhance umbilical blood flow and fetal growth via NO - dependent mechanisms [59], [60].
In pregnancies complicated by fetal congenital heart disease (CHD), global
placental perfusion was significantly decreased and regional variation of
placental perfusion significantly increased as pregnancies progressed, findings that point to non-invasive imaging providing an early warning of placental dysfunction.
«In pregnancies complicated by fetal CHD, global
placental perfusion significantly decreased and regional variation of
placental perfusion significantly increased with advancing gestational age,» says Zungho «Wesley» Zun, Ph.D., the study's lead author.
«Advanced MRI can detect
placental perfusion abnormalities in pregnancies complicated by fetal CHD: Powerful MRI technique shows blood flow complications before placenta damage is consolidated.»
In severe cases, perinatal death may occur, most commonly as a result of poor
placental perfusion due to vascular impairment.