Nitric oxide (NO) and carbon monoxide (CO) are powerful vasodilators that play a role in
the placental vascular system.
Dr. Ray said it's also thought that CP and stillbirths share many common risk factors, including
placental vascular disease in the mother — such things as preeclampsia, gestational hypertension, placental abruption and placental infarction.
In their paper entitled, «Malaria in pregnancy alters L - arginine bioavailability and
placental vascular development,» Science Translational Medicine, 7 March 2018, Toronto General Research Institute (TGRI) and University of Toronto researchers report that Malawian women with malaria in pregnancy had altered levels of L - arginine which were associated with poor birth outcomes.
Infections such as malaria can impair that pathway, restricting
placental vascular development.
Not exact matches
In severe cases, perinatal death may occur, most commonly as a result of poor
placental perfusion due to
vascular impairment.
The implications of these data are that maternal treatment with antioxidants may provide possible therapy against the programming effects on
vascular dysfunction in pregnancy complicated by fetal hypoxia, such as during
placental insufficiency, preeclampsia, gestational diabetes or high altitude pregnancy.
She has been involved in the identification of early biomarkers of
placental damage in cohorts of patients at high risk of pregnancy complications, with specific focus on the role of autoimmunity and of
vascular inflammation.