Given the significant morbidities with multiple cesareans however, including surgical morbidity and abnormal
placentation in future pregnancies, it is important to consider the possibility that for women with more than two prior cesareans VBAC may be associated with less morbidity, particularly in women with a high likelihood of success.
Sean Daneshmand: For example, if a mom comes
in, one of these unattended pregnancies, she comes
in and we realize that she has twins, for example, than, depending on the
placentation, let's say there is one placenta for both babies, so the babies are
in one sack, that is considered a high - risk pregnancy.
Specifically, maternally - inherited DNA methylation marks are important for normal
placentation as they specify cellular properties such as adhesiveness and invasive character, as well as determining the correct balance of cell types needed
in the placenta.»