Plaque rupture is when the fatty deposit (plaque) that builds up inside blood vessels suddenly breaks. This can be risky as it may lead to a blockage in the blood flow, which can cause a heart attack or stroke.
Full definition
But was inflammation relevant to the triggering of actual heart attack — which often occurs when an
arterial plaque ruptures and blocks an artery — not just the long process leading up to it?
Their small size — they are 1,000 times smaller than the tip of a single strand of human hair — and «sticky» surfaces enable them to accumulate and be retained within the plaques to facilitate healing and remodeling to
block plaque rupture and thrombosis.
Cardiologists have well - developed ideas for
how plaque rupture works *; see the concept of â $ œvulnerable plaque.â $ Cholesterol and inflammatory cells build up in the coronary arteries over several years.
This presentation will cover mechanisms of heart attack such as:
spontaneous plaque rupture with clot formation; and, the role of inflammation as a trigger.
The test looks for signs that a patient has experienced an
arterial plaque rupture — a crack in the lining of a blood vessel leading to the heart.
«The leading cause of death worldwide is complications of atherosclerosis, and the most common end - stage disease is when an
atherosclerotic plaque ruptures.
This remodeling of the plaque environment would be predicted in humans to
block plaque rupture and thrombosis and thereby prevent heart attacks and strokes.
«Once
a plaque ruptures, it can induce formation of a large clot that can block blood flow to the downstream regions.
Plaque rupture is a common event directly preceding both heart attack and stroke.
As described in a scientific paper published earlier this year (Nature Genetics, 2004), this risk is probably the result of increased inflammation in atherosclerotic plaques, contributing to
plaque rupture.
Instead of
the plaque rupturing, it's more likely to erode.