Sentences with phrase «plasma cells»
Plasma cells are a type of specialized white blood cell that plays an important role in our immune system. They produce and release antibodies, which are proteins that help our body fight against infections and diseases. When a harmful substance, like a germ, enters our body, plasma cells produce specific antibodies that recognize and attack it. These antibodies can counteract the harmful effects of the germs and help keep us healthy. Full definition
It is basically a proliferation of plasma cells which mimic the existing single cells that usually have multiple bone marrow sites.
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A type of cancer that begins in plasma cells (white blood cells that produce antibodies).
We know little about the specific stimuli that make plasma cell tumors develop but in humans, risk factors include exposure to petroleum products and radiation.
The abnormal plasma cells make M protein, which is sometimes found during a routine blood or urine test.
It specifically affects antibody - producing white blood cells found in the bone marrow, called plasma cells.
Normal plasma cells make antibodies to help the body fight infection and disease.
Animals with plasma cell tumors on the skin do not show signs of illness.
Normally, when bacteria or viruses enter the body, some of the B cells will change into plasma cells.
Oral plasma cell tumors are usually on the lips and gums and are similar in size to those in the skin.
Given their high rates of protein synthesis, antibody - producing plasma cells display particularly high levels of metabolic activity.
Skin plasma cell tumors are raised lumps 1/4 to 3/4 inches in diameter.
Symptoms of feline plasma cell pododermatitis Pododermatitis can affect any footpad, but most commonly it involves the large or central pad of the front or back feet (called the metacarpal or metatarsal pads).
Early Onset, EBV - PTLD in Pediatric Liver - Small Bowel Transplantation Recipients: A Spectrum of Plasma Cell Neoplasms with Favorable Prognosis.
Diagnosis of feline plasma cell pododermatitis If you discover that your cat has soft, swollen, tender, scaly footpads, be sure to bring him to your veterinarian for an examination.
Supportive care is given to treat problems caused by multiple myeloma and other plasma cell neoplasms.
Even though patients with multiple myeloma and other plasma cell disorders may receive an annual flu vaccine, studies show that a one - time flu shot does not offer adequate immune response.
Yale Cancer Center researchers have identified what causes a third of all myelomas, a type of cancer affecting plasma cells.
Multiple myeloma is a rare, malignant plasma cell cancer affecting the bone marrow and other blood producing organs.
This condition is called plasma cell stomatitis or plasmacytic stomatitis.
Multiple myeloma is preceded by a blood disorder called monoclonal gammopathy of undetermined significance (MGUS) in which abnormal plasma cells produce many copies of an antibody protein.
A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins
Repression of the transcription factor Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation.
An electron microscopy image shows an antibody - secreting plasma cell generated using antigen - and CpG - coated nanoparticles.
Fine tuning of IRF - 4 expression by SWAP - 70 controls the initiation of plasma cell development.
«There was some skepticism about whether a CD19 - directed therapy would work in this disease, since nearly all of these patients» cancerous plasma cells do not express CD19,» said the study's senior author, Edward Stadtmauer, MD, chief of Hematologic Malignancies and a professor of Hematology / Oncology in Penn's Abramson Cancer Center and Perelman School of Medicine.
In cancerous plasma cells there is an overproduction of a component of immunoglobulin (any of a group of glycoproteins that act as antibodies in the immune system by binding with the specific antigens) called M component.
Four new regimens — described by Woodle as «second - generation plasma cell - targeted therapies» — will be evaluated by the UC Transplant Clinical Research team in 2015.
IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease
Ebstein - Barr Virus - Negative Clonal Plasma Cell Proliferations Associated With Systemic Involvement of Primary Cutaneous T - Cell Lymphoma
Ebstein - Barr Virus - Negative Clonal Plasma Cell Proliferations Associated With Systemic Involvement of Primary Cutaneous T - Cell Lymphoma We describe a 66 - year - old man with a long - standing history of squamous cell carcinoma of the head and neck region who developed nodular - sclerosing subtype of classical Hodgkin lymphoma and primary cutaneous CD8 - positive, cytotoxic variant of mycosis fungoides over a 1 - year period of time.
The dose - escalation study has shown that higher doses of daratumumab alone can reduce both bone marrow plasma cells as well as paraprotein.
In multiple myeloma, normal plasma cells transform into malignant myeloma cells and produce large quantities of toxic abnormal immunoglobulin called monoclonal protein that can damage multiple organs.
Using a rat model, the researchers, led by Marcus Groettrup, were able to show that immunoproteasome inhibition kills the activated plasma cells that produce allo - antibodies against the transplanted kidneys and lead to organ rejection.
SV = Secretory vesicle; RER = Rough endoplasmic reticulum; BM = Basement membrane; MFG = Milk fat globule; CLD = Cytoplasmic lipid droplet; N = Nucleus; PC = Plasma cell; FDA = Fat - depleted adipocyte; TJ = Tight junction; GJ = Gap junction; D = Desmosome; ME = Myoepithelial cell.
But in multiple myeloma, plasma cells grow out of control in the bone marrow, crowding out healthy cells.
Healthy plasma cells produce antibodies that fight infection in the body, but myeloma cells produce high levels of abnormal antibodies that, when the cancer cells accumulate, they crowd out production of other important blood cells, both red and white.
Most MGUS cases are never diagnosed; MGUS is characterized by a detectable M protein without evidence for end - organ damage or other related plasma cell or lymphoproliferative disorders.
«Together,» explains Dr. Ramiro, «the results indicate that CTCF is important for maintaining the germinal center differentiation program and prevents premature differentiation towards plasma cells.»
Multiple myeloma is a cancer of the infection - fighting plasma cells, part of the immune system found mainly in bone marrow.
«Bortezomib is capable of treating the causes of the disease by eliminating plasma cells.
Since 2008, the UC research team has been on forefront of developing therapies that target plasma cells — the cells that make antibodies.
GigaGen captured millions - diverse DNA libraries from B cell and plasma cell repertoires from human donors and used these libraries to manufacture recombinant IgG proteins.
SWAP - 70 deficiency causes high - affinity plasma cell generation despite impaired germinal center formation.
When plasma cells become malignant, they affect healthy blood cell production, which weakens the immune system.
External radiation therapy is used to treat plasma cell neoplasms.
Beta -2-microglobulin is a protein found on plasma cells.