Low - fat diets do not lower
plasma cholesterol levels in healthy men compared to high - fat diets with similar fatty acid composition at constant caloric intake
Nutritional benefits of kangaroo meat for people advised to follow cholesterol - lowering diets were discussed by O'Dea (1988) who conducted research which showed that both Aboriginal Australians and Australians of European origin had 19 - 24 %
lower plasma cholesterol levels following 2 weeks on a diet containing 500g / day of kangaroo meat.
Here, we used sequencing - by - ligation to sequence the genome of an 11 - month - old breast - fed girl with xanthomas and very
high plasma cholesterol levels (1023 mg / dl).
Studies of lipid metabolism, at Gladstone and elsewhere, have provided insights and expertise that are applied to caring for patients
with plasma cholesterol levels that are difficult to manage.
Western - type diets induce insulin resistance and hyperinsulinemia in LDL receptor - deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which
similar plasma cholesterol levels are achieved by a fructose - rich diet.
Interestingly, a reduction of ApoC - III had variable effects
on plasma cholesterol levels, reducing levels in Ndst1fl / fl Alb - Cre +, Ldlr — / — , and Ldlr — / — Ndst1fl / fl Alb - Cre + mice by 30 % to 40 % (Supplemental Figure 3).
After consuming a diet with a high fat content (greater than 100 g fat / day) for two weeks, the
mean plasma cholesterol level increased (p less than 0.02) while the mean SHBG level decreased (p less than 0.02).
ApoC - III ASO treatment did not alter
fasting plasma cholesterol levels (Figure 1F and Supplemental Figure 1F) or lipoprotein cholesterol levels in chow - fed animals (Figure 2, G — L).
The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate
the plasma cholesterol level in man.
Estimates were derived using Cox regression adjusted for age, sex, smoking status, cumulative tobacco consumption, alcohol consumption, leisure - time physical activity, income, and
plasma cholesterol level.