Sentences with phrase «plasma homocysteine levels»

In a sample of 1,092 men and women without dementia followed for an average of 10 years, those with higher plasma homocysteine levels at baseline had a significantly higher risk of developing Alzheimer's disease and other types of dementia.

However, when methionine - rich diets are used to induce hyperhomocysteinemia... Mice fed methionine - rich diets had significant atheromatous pathology in the aortic arch even with normal plasma homocysteine levels, whereas mice fed B vitamin - deficient diets developed severe hyperhomocysteinemia without any increase in vascular pathology.

Several factors influence plasma homocysteine levels, such as intake of folic acid and vitamin B12, age, gender, heredity, smoking, hypertension, and physical activity39.

In addition, no causal relationship has been established between high total plasma homocysteine levels (tHCYs) and cardiovascular disease43.

Low serum levels of certain B vitamins (folate and vitamins B12 and B6) have been associated with elevated plasma homocysteine levels in several studies and with an increased risk of dementia in a few investigations.38 - 42 In our study, the observed association between plasma homocysteine and risk of dementia was not significantly altered by adjustment for the plasma levels of these vitamins (Table 3).

Specifically, those with plasma homocysteine levels greater than 14 μmol / L had nearly double the risk of developing Alzheimer's disease (47).

+ / + - Homozygotes for this variant allele in the CTH gene had significantly higher plasma homocysteine levels than other genotypes in a cohort of 496 Caucasian individuals.

RESULTS: Plasma homocysteine levels were not affected by diet.