(A — F) Mutant mice of the indicated genotypes that were fed a high - fat diet for 6 weeks were treated for the last 5 weeks with control or ApoC - III ASO, and pooled
plasma lipoproteins from fasted animals were analyzed by size - exclusion FPLC (n = 3 / pool).
Not exact matches
Similar results were obtained when overnight - fasted mice were orally gavaged with a bolus of corn oil containing [3H] retinol (the disappearance of [3H] retinol
from plasma is a direct measure of hepatic clearance of intestinally derived
lipoproteins)(Figure 4, C — I).
(D)
Lipoprotein cholesterol profiles in
plasma from fasted iLpldf mice treated with control ASO or ApoC - III ASO (4 weeks, n = 3 mice / pool).
(C)
Lipoprotein TG profiles in
plasma from pooled, fasted iLpldf mice treated with tamoxifen to induce inactivation of LPL expression (iLpldf)(n = 3 pooled mice / group).
Lipoprotein fractions were prepared
from plasma by sequential ultracentrifugation.18 Cholesterol and TG contents were determined by automated chemical analysis.
«While the major CVD benefit of statins is due to reduction in
plasma low density
lipoprotein cholesterol (LDL - C), [2] statins also produce moderate increases, ranging
from 4 % to 10 %, in levels of high density
lipoprotein cholesterol (HDL - C).