Muscle contraction is initiated when action
potentials fired at the end - plate of the muscle cells propagate throughout the
plasma membrane and trigger a conformational change of the voltage-gated CAV1.1 Ca2 + + channel (also called dihydropyridine receptor, DHPR).
During an action
potential, calcium influx into the presynaptic terminal triggers the fusion of synaptic vesicles with the
plasma membrane, leading to the release of transmitter through the process of exocytosis.