In a 2007 study, adults ages 55 to 87 had
lower plasma zinc and higher oxidative stress and inflammatory markers compared to younger adults.
Patients with hypothyroidism may have impaired intestinal zinc absorption and lower levels
of plasma zinc (4,5).
Results from a large cross-sectional survey suggest that 44 % of children with sickle cell disease have a low
plasma zinc concentration [42], possibly due to increased nutrient requirements and / or poor nutritional status [43].
Such low concentrations
of plasma zinc have been linked with disease progression, independent of baseline CD4 cell count, lymphocyte concentrations and age - and calorie - adjusted dietary intake (Falutz et al. 1988, Graham et al. 1991).
Of particular importance,
low plasma zinc levels have been associated with a threefold increased risk of HIV - 1 — related death in HIV - 1 — seropositive drug users (Baum et al. 1997b).
Even though
plasma zinc is an acute phase reactant that may change in response to metabolic alterations, plasma zinc levels react to dietary intake in a rapid and measurable manner (Gershwin et al. 1985, Keen 1990).
Stabile, A., Pesaresi, M. A., Stabile, A. M., Pastore, M., Sopo, S. M., Ricci, R., Celestini, E., and Segni, G. Immunodeficiency and
plasma zinc levels in children with Down's syndrome: a long - term follow - up of oral zinc supplementation.