Sentences with phrase «plays in human disease»

By building this selective set of compounds and making it freely available, UNC - Chapel Hill and its partners are offering the scientific community a better understanding of the roles the kinome plays in human disease and the ability to collaborate on the discovery and advancement of new therapies.

Not exact matches

According to the University of Maryland Medical Center polyunsaturated fatty acids (PUFAs)-- also known as omega - 3 fatty acids — play a crucial role in human brain function, as well as normal growth and development, with research showing that they can also reduce inflammation in addition to helping lower the risk of chronic diseases such as heart disease, cancer, and arthritis.

Human breast milk that is frozen or stored for longer than 48 hours loses a significant amount of its antioxidant content, making it less able to help infants fight off free radicals that play a role in allowing infections and other diseases.

«There are many studies in humans, and at least one in chimpanzees, showing that from an immunological perspective, juveniles and children are really important for maintaining diseases in populations through play and things like that,» she said.

Since these behaviors are similar to behavioral traits in humans with schizophrenia, this suggests that KMO and KYNA may play a key role in the disease.

It is important for NASA to learn how bacterial communities that play roles in human health and disease are affected by spaceflight.

• In other funding news, the National Institutes of Health announced a new $ 17 million program to investigate whether extracellular RNA plays an important signaling role in people, and whether it can be harnessed to diagnose and treat human diseases, Mitch Leslie reports in News & AnalysiIn other funding news, the National Institutes of Health announced a new $ 17 million program to investigate whether extracellular RNA plays an important signaling role in people, and whether it can be harnessed to diagnose and treat human diseases, Mitch Leslie reports in News & Analysiin people, and whether it can be harnessed to diagnose and treat human diseases, Mitch Leslie reports in News & Analysiin News & Analysis.

The Duke medical researchers and ecologists who have joined that project hope to identify which species flourish in early stages of the human microbiome, how they are influenced by the consumption of breast milk, and what role they play in critical diseases affecting infants as well as in chronic diseases that occur later in life.

Now, a study published online April 27th, in the Journal of Immunology, confirms that the cytokine GM - CSF (Granulocyte macrophage colony - stimulating factor) likely plays an important role in human disease and offers a new explanation for why the MS treatment interferon - Beta (INF - β) is often effective at reducing MS attacks.

«We are only beginning to understand the role that human - made chemicals play in causing human disease,» said Regnier.

The hormone estrogen plays an important role in the human body and has been linked to everything from tumor growth to neuron loss during Alzheimer's disease.

«Tiny mitochondria play outsized role in human evolution and disease.»

While genetics play a role in the development of Lupus, a systemic autoimmune disease that can attack any organ system in the human body, so do environmental triggers, such as particulates in air pollution and ultraviolet light, explains Gaurav Gulati, MD, a physician - researcher at the University of Cincinnati (UC) College of Medicine.

Transport of engineered nano - particles loaded with drugs or bio-molecules to the site of the disease in pathophysiologic states in humans plays a critical role in determining the efficacy of therapeutic management.

This suggests that ATP7B and ATP7A play antagonistic roles in copper homeostasis, and that attenuation of copper accumulation by mutation of ATP7A could ameliorate symptoms of Wilson disease in humans.

A new study has found that nearly half of camels in parts of Kenya have been infected by the virus that causes Middle East Respiratory Syndrome (MERS) and calls for further research into the role they might play in the transmission of this emerging disease to humans.

Almost 100 trillion microbes — some beneficial and some harmful — live in the human gastrointestinal tract at any time, helping to regulate immune function and inflammation, two factors hypothesized to play a role in neurodegenerative diseases like Parkinson's and Alzheimer's.

This discovery plays a primordial role in understanding immune system diseases in humans.

Scientists are only beginning to understand what role the billions of microbial cells colonizing the human gut play in diet and disease.

«Although I wholeheartedly agree that rare variants play a substantial role in human diseases, I also think that the section on GWAS reflects misunderstandings of the concept of GWAS, ignorance of standard practices in GWAS, misinterpretation of published primary research data, and as a result, is misinforming the general readership of Cell,» wrote Kai Wang, a postdoc at Children's Hospital of Philadelphia whose papers were cited in the Cell article.

Next - generation sequencing — the ability to sequence millions or billions of small fragments of DNA in parallel — has revolutionized the biological sciences, playing an essential role in everything from locating mutations that cause human disease to determining how a newly discovered animal fits into the tree of life.

The Wnt pathway is found throughout the animal kingdom — from sponges to humans — and it plays a fundamental role in animal development and disease.

A human protein known as prohibitin may play a significant role in infection of the nervous system by EV71, one of several viruses that can cause hand, foot, and mouth disease.

«We would also now like to broaden this research to see how much this process may play a similar role in other major human diseases.»

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

This discovery provides a significant opportunity not only to enhance our understanding of how miRNAs regulate a variety of biological processes in an important model species for studying human diseases, but can lead to further, similar research into the role that miRNAs play in animal domestication.

«This is a stunner,» says Francis Collins, director of the National Human Genome Research Institute in Bethesda, Maryland, and a co-author of one of last week's diabetes papers, because it suggests the same gene could play a role in both diseases.

Microbes have a profound effect on many human physiological processes, such as digestion and drug metabolism, and play a vital role in disease susceptibility.

«While we are only just beginning to understand the complex roles microbes play in human biology, it is clear specific changes in microbial flora are associated with — and sometimes cause or cure — disease in the host,» said Pollard while explaining her research focus.

Studying zebrafish is a vitally important way to discover what role genes play in human health and disease.

It is becoming apparent that other key members of the microbiome like fungi and viruses may play a key role in human health and disease [31] and understanding these dynamics will be imperative if we are to improve these conditions.

«Microbes play a significant role in the health of the digestive tract and many digestive diseases result when the microbial environment is out of balance,» said Griffin P. Rodgers, M.D., M.A.C.P., director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and co-chair of the Human Microbiome Project's Implementation Group.

«Microbiology is coming to a point where it's extraordinarily evident that bacteria, fungi and viruses play a massive role in the development of health and disease in humans, in environmental settings and ecological systems,» said Jack Gilbert, PhD, associate professor in the Department of Ecology & Evolution at the University of Chicago.

The diverse set of antagonists described in this article will be useful in guiding medicinal chemists to rationally design effective CXCR4 antagonists for the treatment of human diseases where SDF - 1 / CXCR4 axis plays a critical role.

In this research position you will play a leading role in discovering and advancing compounds for the treatment of major human diseaseIn this research position you will play a leading role in discovering and advancing compounds for the treatment of major human diseasein discovering and advancing compounds for the treatment of major human diseases.

«Inflammation plays a central role in many diseases, cancer, arteriosclerosis, rheumatoid arthritis, infections, in fact, inflammation is a major cause of human misery,» says Inder Verma, professor in the Laboratory of Genetics and lead scientist of both studies.

Research suggests that random fluctuations in gene activity could explain some instances of the phenomenon, known as partial penetrance, which likely plays a role in some human diseases.

In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writIn the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writin Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writin gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they write.

This study of human genetic variation and its relationship to health and disease involves a large number of study participants and will capture not only common single nucleotide variations but also rare copy number and structural variants that are increasingly thought to play an important role in complex disease.

«To then determine how disrupting the gene might play out in the context of disease, we chemically knocked out the activity of SLC16A11 in human liver cells,» explains co-first author Victor Rusu, a former Harvard graduate student at Broad now at Jnana Therapeutics.

Identity by descent (IBD) has played a fundamental role in the discovery of genetic loci underlying human diseases.

September 27, 2000 Prions may play crucial role in evolution Prions, abnormally folded proteins associated with several bizarre human diseases, may hold the key to a major mystery in evolution — how survival skills that require multiple genetic changes arise all at once when each genetic change by itself would be unsuccessful and even harmful.

By supporting Directive 2010 / 63 / EU, LERU wishes to call attention to the fundamental importance of the use of animals in research and the vital role it plays in understanding and providing treatment for a range of debilitating and life threatening human diseases such as cancer, primary immunodeficiencies, neuro - degenerative diseases and heart failure.

According to the scientists, these results show that although the gene variants — which make individual humans different from each other — in general have a small impact on disease development, the gene switches in which they reside can play a major role.

«It's critical that we more clearly understand the role that human decisions play in transmitting disease.»

Because of the pivotal role that diet plays in causing the MS in humans, most metabolic disease animal models do (and we believe should) use diet as a way to precipitate this syndrome.

According to the report, that complexity - including the sum of genetic, environmental, and life - stage factors that play a part in the onset of human disease - should now be addressed by bringing together emerging new tools and methods that give scientists insight into the 100,000 chemicals routinely used in commerce but largely untested for health effects.

Williams, who studies diseases that are differentially distributed among human populations, uses the tools of evolutionary biology to examine the role that genetics plays in health disparities.

We are identifying genes that alter atherosclerosis susceptibility in a mouse model and testing whether they play a role in coronary artery disease in humans.

Because programmed cell death goes awry in leukemias and other cancers, Hu is currently examining lincRNA - EPS's function in normal and diseased human cells in an effort to determine whether it plays a role in tumor development and growth.